Responses and functions of dopamine in nucleus accumbens core during social behaviors
Social behaviors are among the most important motivated behaviors. How dopamine (DA), a “reward” signal, releases during social behaviors has been a topic of interest for decades. Here, we use a genetically encoded DA sensor, GRABDA2m, to record DA activity in the nucleus accumbens (NAc) core during...
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Veröffentlicht in: | Cell reports (Cambridge) 2022-08, Vol.40 (8), p.111246-111246, Article 111246 |
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Sprache: | eng |
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Zusammenfassung: | Social behaviors are among the most important motivated behaviors. How dopamine (DA), a “reward” signal, releases during social behaviors has been a topic of interest for decades. Here, we use a genetically encoded DA sensor, GRABDA2m, to record DA activity in the nucleus accumbens (NAc) core during various social behaviors in male and female mice. We find that DA releases during approach, investigation and consummation phases of social behaviors signal animals’ motivation, familiarity of the social target, and valence of the experience, respectively. Positive and negative social experiences evoke opposite DA patterns. Furthermore, DA releases during mating and fighting are sexually dimorphic with a higher level in males than in females. At the functional level, increasing DA in NAc enhances social interest toward a familiar conspecific and alleviates defeat-induced social avoidance. Altogether, our results reveal complex information encoded by NAc DA activity during social behaviors and their multistage functional roles.
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•DA in NAc core during social approach signals motivation•DA in NAc core during social investigation signals novelty of the social target•DA in NAc core during social actions signals valence and is sexually dimorphic•Increase NAc DA promotes social interest and alleviates defeat-induced avoidance
Dai et al. report complex and sexually dimorphic DA release in nucleus accumbens (NAc) core during various social behaviors in mice. DA release during approach, investigation, and action phases of social behaviors carries distinct information. When DA release is artificially boosted, it enhances social interest and reduces defeat-induced social avoidance. |
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ISSN: | 2211-1247 2211-1247 |
DOI: | 10.1016/j.celrep.2022.111246 |