Durability of Booster mRNA Vaccine against SARS-CoV-2 BA.2.12.1, BA.4, and BA.5 Subvariants

After a third (booster) dose of SARS-CoV-2 vaccine, immunity waned more slowly than after two doses and even more slowly in persons with breakthrough Covid-19. Neutralization of subvariant BA.4–BA.5 was particularly resistant to vaccine-induced immunity.

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Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2022-10, Vol.387 (14), p.1329-1331
Hauptverfasser:	Qu, Panke, Faraone, Julia N., Evans, John P., Zheng, Yi-Min, Yu, Lianbo, Ma, Qin, Carlin, Claire, Lozanski, Gerard, Saif, Linda J., Oltz, Eugene M., Gumina, Richard J., Liu, Shan-Lu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Coronavirus Coronaviruses Correspondence COVID-19 COVID-19 - etiology COVID-19 - prevention & control COVID-19 Vaccines - immunology COVID-19 Vaccines - therapeutic use Humans Hypothesis testing Immunization, Secondary Infections Infectious Disease mRNA mRNA vaccines mRNA Vaccines - immunology mRNA Vaccines - therapeutic use Mutation RNA, Messenger SARS-CoV-2 - genetics SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Trends Vaccine Efficacy Vaccines Vaccines, Synthetic - immunology Vaccines, Synthetic - therapeutic use Viral Infections
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Beschreibung
Zusammenfassung:	After a third (booster) dose of SARS-CoV-2 vaccine, immunity waned more slowly than after two doses and even more slowly in persons with breakthrough Covid-19. Neutralization of subvariant BA.4–BA.5 was particularly resistant to vaccine-induced immunity.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMc2210546