Nationwide evaluation of mutation-tailored anti-EGFR therapy selection in patients with colorectal cancer in daily clinical practice

Nationwide evaluation of mutation-tailored anti-EGFR therapy selection in patients with colorectal cancer in daily clinical practice

For a nationwide real-word data study on the application of predictive mutation testing of patients with colorectal cancer (CRC) for anti-epidermal growth factor receptor (EGFR) therapy stratification, pathology data were collected from the Dutch Pathology Registry from October 2017 until June 2019...

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Veröffentlicht in:Journal of clinical pathology 2022-10, Vol.75 (10), p.706-711
Hauptverfasser: Steeghs, Elisabeth M P, Vink, Geraldine R, Elferink, Marloes A G, Voorham, Quirinus J M, Gelderblom, Hans, Nagtegaal, Iris D, Grünberg, Katrien, Ligtenberg, Marjolijn J L, Drillenburg, P, Nijhuis, E W P, van de Vijver, M J, van Noesel, C J, Bloemena, E, Heideman, D A M, Radonic, T, Thunissen, E, Nederlof, P M, Meijer, G A, Monkhorst, K, Doornewaard, H, Dijk, M C R F van, Ruijter, E, Duthoi, K, Meijers, C, van de Brule, A J C, Nooijen, P T G A, Bot, F J, Hazalbag, H M, Clahsen, P, van Nederveen, F H, Westenend, P J, Jeuken, J W M, Ahsmann, E J M, Meulbroek, P, Timens, W, Schuuring, E, van Kempen, L C, Geuken, W, Bulkmans, N W J, Bellot, F E, Clarijs, R, Riemersma, S, van der Geize, R, Meijer, J, van Slooten, H J, Kibbelaar, R E, van der Logt, E M J, van Wezel, T, Morreau, H, Bovee, J V M G, Zur Hausen, A, Speel, E J M, de Bruin, P C, Huijsmans, C J, Dusseljee, S, Willems, R W, Prinsen, C F, Zomer, S, van Kemenade, F J, Dinjens, W N M, Geurts-Giele, W R R, van der Valk, H, Smits, A J J, Hoogduin, K J, Kliffen, M, den Bakker, M A, Stavast, J, van Diest, P J, de Leng, W W J, de Bruïne, A P, Hinrichs, J W J, Meischl, C, Gaal, J, Niemantsverdriet, M
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Cancer therapies
Clinical medicine
Colorectal cancer
colorectal neoplasms
Data collection
Datasets
Departments
diagnostic techniques and procedures
Genes
Metastasis
molecular
Mutation
Pathology
Patients
Short Report
Tumors
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Beschreibung
Zusammenfassung:For a nationwide real-word data study on the application of predictive mutation testing of patients with colorectal cancer (CRC) for anti-epidermal growth factor receptor (EGFR) therapy stratification, pathology data were collected from the Dutch Pathology Registry from October 2017 until June 2019 (N=4060) and linked with the Netherlands Cancer Registry. Mutation testing rates increased from 24% at diagnosis of stage IV disease to 60% after 20–23 months of follow-up (p
ISSN:0021-9746
1472-4146
1472-4146
DOI:10.1136/jclinpath-2021-207865