PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer
Sixteen patients with mismatch repair–deficient, locally advanced rectal cancer were enrolled in a pilot study in which 6 months of neoadjuvant anti–PD-1 therapy was to be followed by surgical resection. Twelve patients have completed treatment and have had at least 6 months of follow-up; all 12 had...
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| Veröffentlicht in: | The New England journal of medicine 2022-06, Vol.386 (25), p.2363-2376 |
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| container_title | The New England journal of medicine |
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| creator | Cercek, Andrea Lumish, Melissa Sinopoli, Jenna Weiss, Jill Shia, Jinru Lamendola-Essel, Michelle El Dika, Imane H. Segal, Neil Shcherba, Marina Sugarman, Ryan Stadler, Zsofia Yaeger, Rona Smith, J. Joshua Rousseau, Benoit Argiles, Guillem Patel, Miteshkumar Desai, Avni Saltz, Leonard B. Widmar, Maria Iyer, Krishna Zhang, Janie Gianino, Nicole Crane, Christopher Romesser, Paul B. Pappou, Emmanouil P. Paty, Philip Garcia-Aguilar, Julio Gonen, Mithat Gollub, Marc Weiser, Martin R. Schalper, Kurt A. Diaz, Luis A. |
| description | Sixteen patients with mismatch repair–deficient, locally advanced rectal cancer were enrolled in a pilot study in which 6 months of neoadjuvant anti–PD-1 therapy was to be followed by surgical resection. Twelve patients have completed treatment and have had at least 6 months of follow-up; all 12 had a clinical complete response. All imaging tests and biopsies have shown no viable tumor. |
| doi_str_mv | 10.1056/NEJMoa2201445 |
| format | Article |
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Joshua ; Rousseau, Benoit ; Argiles, Guillem ; Patel, Miteshkumar ; Desai, Avni ; Saltz, Leonard B. ; Widmar, Maria ; Iyer, Krishna ; Zhang, Janie ; Gianino, Nicole ; Crane, Christopher ; Romesser, Paul B. ; Pappou, Emmanouil P. ; Paty, Philip ; Garcia-Aguilar, Julio ; Gonen, Mithat ; Gollub, Marc ; Weiser, Martin R. ; Schalper, Kurt A. ; Diaz, Luis A.</creator><creatorcontrib>Cercek, Andrea ; Lumish, Melissa ; Sinopoli, Jenna ; Weiss, Jill ; Shia, Jinru ; Lamendola-Essel, Michelle ; El Dika, Imane H. ; Segal, Neil ; Shcherba, Marina ; Sugarman, Ryan ; Stadler, Zsofia ; Yaeger, Rona ; Smith, J. Joshua ; Rousseau, Benoit ; Argiles, Guillem ; Patel, Miteshkumar ; Desai, Avni ; Saltz, Leonard B. ; Widmar, Maria ; Iyer, Krishna ; Zhang, Janie ; Gianino, Nicole ; Crane, Christopher ; Romesser, Paul B. ; Pappou, Emmanouil P. ; Paty, Philip ; Garcia-Aguilar, Julio ; Gonen, Mithat ; Gollub, Marc ; Weiser, Martin R. ; Schalper, Kurt A. ; Diaz, Luis A.</creatorcontrib><description>Sixteen patients with mismatch repair–deficient, locally advanced rectal cancer were enrolled in a pilot study in which 6 months of neoadjuvant anti–PD-1 therapy was to be followed by surgical resection. Twelve patients have completed treatment and have had at least 6 months of follow-up; all 12 had a clinical complete response. All imaging tests and biopsies have shown no viable tumor.</description><identifier>ISSN: 0028-4793</identifier><identifier>EISSN: 1533-4406</identifier><identifier>DOI: 10.1056/NEJMoa2201445</identifier><identifier>PMID: 35660797</identifier><language>eng</language><publisher>United States: Massachusetts Medical Society</publisher><subject>Adenocarcinoma ; Antibodies, Monoclonal, Humanized ; Antineoplastic Agents - therapeutic use ; Antineoplastic Combined Chemotherapy Protocols - adverse effects ; Biopsy ; Cancer therapies ; Chemoradiotherapy ; Chemoradiotherapy - adverse effects ; Chemotherapy ; Colorectal cancer ; Colorectal carcinoma ; DNA Mismatch Repair ; Endoscopy ; Enrollments ; FDA approval ; Gastroenterology ; Gastrointestinal Tract Cancer ; Hematology ; Humans ; Immune checkpoint ; Immunotherapy ; Magnetic resonance imaging ; Metastases ; Metastasis ; Mismatch repair ; Monoclonal antibodies ; Neoadjuvant Therapy - methods ; Neoplasm Staging ; Neoplasms, Second Primary - pathology ; Oncology ; Patients ; PD-1 protein ; Positron emission tomography ; Programmed Cell Death 1 Receptor - drug effects ; Prospective Studies ; Radiation ; Rectal Neoplasms - genetics ; Rectal Neoplasms - therapy ; Rectum ; Rectum - pathology ; Software ; Statistical analysis ; Surgery ; Targeted cancer therapy ; Tomography ; Treatment Outcome ; Treatments in Oncology ; Tumors</subject><ispartof>The New England journal of medicine, 2022-06, Vol.386 (25), p.2363-2376</ispartof><rights>Copyright © 2022 Massachusetts Medical Society. All rights reserved.</rights><rights>Copyright © 2022 Massachusetts Medical Society.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c599t-64703e31252f5db453ae538c04dae6527926ef02fd5c193ac29d9cb50727cff63</citedby><cites>FETCH-LOGICAL-c599t-64703e31252f5db453ae538c04dae6527926ef02fd5c193ac29d9cb50727cff63</cites><orcidid>0000-0003-4173-5567</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.nejm.org/doi/pdf/10.1056/NEJMoa2201445$$EPDF$$P50$$Gmms$$H</linktopdf><linktohtml>$$Uhttps://www.nejm.org/doi/full/10.1056/NEJMoa2201445$$EHTML$$P50$$Gmms$$H</linktohtml><link.rule.ids>230,314,776,780,881,2746,2747,26080,27901,27902,52357,54039</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35660797$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Cercek, Andrea</creatorcontrib><creatorcontrib>Lumish, Melissa</creatorcontrib><creatorcontrib>Sinopoli, Jenna</creatorcontrib><creatorcontrib>Weiss, Jill</creatorcontrib><creatorcontrib>Shia, Jinru</creatorcontrib><creatorcontrib>Lamendola-Essel, Michelle</creatorcontrib><creatorcontrib>El Dika, Imane H.</creatorcontrib><creatorcontrib>Segal, Neil</creatorcontrib><creatorcontrib>Shcherba, Marina</creatorcontrib><creatorcontrib>Sugarman, Ryan</creatorcontrib><creatorcontrib>Stadler, Zsofia</creatorcontrib><creatorcontrib>Yaeger, Rona</creatorcontrib><creatorcontrib>Smith, J. Joshua</creatorcontrib><creatorcontrib>Rousseau, Benoit</creatorcontrib><creatorcontrib>Argiles, Guillem</creatorcontrib><creatorcontrib>Patel, Miteshkumar</creatorcontrib><creatorcontrib>Desai, Avni</creatorcontrib><creatorcontrib>Saltz, Leonard B.</creatorcontrib><creatorcontrib>Widmar, Maria</creatorcontrib><creatorcontrib>Iyer, Krishna</creatorcontrib><creatorcontrib>Zhang, Janie</creatorcontrib><creatorcontrib>Gianino, Nicole</creatorcontrib><creatorcontrib>Crane, Christopher</creatorcontrib><creatorcontrib>Romesser, Paul B.</creatorcontrib><creatorcontrib>Pappou, Emmanouil P.</creatorcontrib><creatorcontrib>Paty, Philip</creatorcontrib><creatorcontrib>Garcia-Aguilar, Julio</creatorcontrib><creatorcontrib>Gonen, Mithat</creatorcontrib><creatorcontrib>Gollub, Marc</creatorcontrib><creatorcontrib>Weiser, Martin R.</creatorcontrib><creatorcontrib>Schalper, Kurt A.</creatorcontrib><creatorcontrib>Diaz, Luis A.</creatorcontrib><title>PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer</title><title>The New England journal of medicine</title><addtitle>N Engl J Med</addtitle><description>Sixteen patients with mismatch repair–deficient, locally advanced rectal cancer were enrolled in a pilot study in which 6 months of neoadjuvant anti–PD-1 therapy was to be followed by surgical resection. Twelve patients have completed treatment and have had at least 6 months of follow-up; all 12 had a clinical complete response. All imaging tests and biopsies have shown no viable tumor.</description><subject>Adenocarcinoma</subject><subject>Antibodies, Monoclonal, Humanized</subject><subject>Antineoplastic Agents - therapeutic use</subject><subject>Antineoplastic Combined Chemotherapy Protocols - adverse effects</subject><subject>Biopsy</subject><subject>Cancer therapies</subject><subject>Chemoradiotherapy</subject><subject>Chemoradiotherapy - adverse effects</subject><subject>Chemotherapy</subject><subject>Colorectal cancer</subject><subject>Colorectal carcinoma</subject><subject>DNA Mismatch Repair</subject><subject>Endoscopy</subject><subject>Enrollments</subject><subject>FDA approval</subject><subject>Gastroenterology</subject><subject>Gastrointestinal Tract Cancer</subject><subject>Hematology</subject><subject>Humans</subject><subject>Immune checkpoint</subject><subject>Immunotherapy</subject><subject>Magnetic resonance imaging</subject><subject>Metastases</subject><subject>Metastasis</subject><subject>Mismatch repair</subject><subject>Monoclonal antibodies</subject><subject>Neoadjuvant Therapy - methods</subject><subject>Neoplasm Staging</subject><subject>Neoplasms, Second Primary - pathology</subject><subject>Oncology</subject><subject>Patients</subject><subject>PD-1 protein</subject><subject>Positron emission tomography</subject><subject>Programmed Cell Death 1 Receptor - drug effects</subject><subject>Prospective Studies</subject><subject>Radiation</subject><subject>Rectal Neoplasms - genetics</subject><subject>Rectal Neoplasms - therapy</subject><subject>Rectum</subject><subject>Rectum - pathology</subject><subject>Software</subject><subject>Statistical analysis</subject><subject>Surgery</subject><subject>Targeted cancer therapy</subject><subject>Tomography</subject><subject>Treatment Outcome</subject><subject>Treatments in Oncology</subject><subject>Tumors</subject><issn>0028-4793</issn><issn>1533-4406</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><sourceid>BEC</sourceid><sourceid>BENPR</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNp1kMtKAzEUhoMotlaXbmVA3Dma-zQbobb1Rqsiug5pJmNT51KTaaE738E39ElMaS26MJtDOB_f-fkBOETwDEHGz-_7d8NKYQwRpWwLNBEjJKYU8m3QhBC3Y5oI0gB73k9geIiKXdAgjHOYiKQJBo-9GEWXeaXfVGoiW0ZD6wtV63H0ZKbKuq-Pz57JrLamrE-jQaVVni-iTjpXpTZpgHSt8qi7_Ll9sJOp3JuD9WyBl6v-c_cmHjxc33Y7g1gzIeqY0wQSQxBmOGPpiDKiDCNtDWmqDGc4EZibDOIsZRoJojQWqdAjBhOc6CzjpAUuVt7pbFSYVIdoTuVy6myh3EJWysq_m9KO5Ws1l4IKTCAKguO1wFXvM-NrOalmrgyZJeahF044agcqXlHaVd47k20uICiX5cs_5Qf-6HesDf3TdgBOVkBReFmaSfGP6Bv9PosE</recordid><startdate>20220623</startdate><enddate>20220623</enddate><creator>Cercek, Andrea</creator><creator>Lumish, Melissa</creator><creator>Sinopoli, Jenna</creator><creator>Weiss, Jill</creator><creator>Shia, Jinru</creator><creator>Lamendola-Essel, Michelle</creator><creator>El Dika, Imane H.</creator><creator>Segal, Neil</creator><creator>Shcherba, Marina</creator><creator>Sugarman, Ryan</creator><creator>Stadler, Zsofia</creator><creator>Yaeger, Rona</creator><creator>Smith, J. 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| identifier | ISSN: 0028-4793 |
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| source | MEDLINE; New England Journal of Medicine Current; EZB Electronic Journals Library |
| subjects | Adenocarcinoma Antibodies, Monoclonal, Humanized Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Biopsy Cancer therapies Chemoradiotherapy Chemoradiotherapy - adverse effects Chemotherapy Colorectal cancer Colorectal carcinoma DNA Mismatch Repair Endoscopy Enrollments FDA approval Gastroenterology Gastrointestinal Tract Cancer Hematology Humans Immune checkpoint Immunotherapy Magnetic resonance imaging Metastases Metastasis Mismatch repair Monoclonal antibodies Neoadjuvant Therapy - methods Neoplasm Staging Neoplasms, Second Primary - pathology Oncology Patients PD-1 protein Positron emission tomography Programmed Cell Death 1 Receptor - drug effects Prospective Studies Radiation Rectal Neoplasms - genetics Rectal Neoplasms - therapy Rectum Rectum - pathology Software Statistical analysis Surgery Targeted cancer therapy Tomography Treatment Outcome Treatments in Oncology Tumors |
| title | PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer |
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