PD-1 Blockade in Mismatch Repair–Deficient, Locally Advanced Rectal Cancer

Sixteen patients with mismatch repair–deficient, locally advanced rectal cancer were enrolled in a pilot study in which 6 months of neoadjuvant anti–PD-1 therapy was to be followed by surgical resection. Twelve patients have completed treatment and have had at least 6 months of follow-up; all 12 had...

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Veröffentlicht in:	The New England journal of medicine 2022-06, Vol.386 (25), p.2363-2376
Hauptverfasser:	Cercek, Andrea, Lumish, Melissa, Sinopoli, Jenna, Weiss, Jill, Shia, Jinru, Lamendola-Essel, Michelle, El Dika, Imane H., Segal, Neil, Shcherba, Marina, Sugarman, Ryan, Stadler, Zsofia, Yaeger, Rona, Smith, J. Joshua, Rousseau, Benoit, Argiles, Guillem, Patel, Miteshkumar, Desai, Avni, Saltz, Leonard B., Widmar, Maria, Iyer, Krishna, Zhang, Janie, Gianino, Nicole, Crane, Christopher, Romesser, Paul B., Pappou, Emmanouil P., Paty, Philip, Garcia-Aguilar, Julio, Gonen, Mithat, Gollub, Marc, Weiser, Martin R., Schalper, Kurt A., Diaz, Luis A.
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenocarcinoma Antibodies, Monoclonal, Humanized Antineoplastic Agents - therapeutic use Antineoplastic Combined Chemotherapy Protocols - adverse effects Biopsy Cancer therapies Chemoradiotherapy Chemoradiotherapy - adverse effects Chemotherapy Colorectal cancer Colorectal carcinoma DNA Mismatch Repair Endoscopy Enrollments FDA approval Gastroenterology Gastrointestinal Tract Cancer Hematology Humans Immune checkpoint Immunotherapy Magnetic resonance imaging Metastases Metastasis Mismatch repair Monoclonal antibodies Neoadjuvant Therapy - methods Neoplasm Staging Neoplasms, Second Primary - pathology Oncology Patients PD-1 protein Positron emission tomography Programmed Cell Death 1 Receptor - drug effects Prospective Studies Radiation Rectal Neoplasms - genetics Rectal Neoplasms - therapy Rectum Rectum - pathology Software Statistical analysis Surgery Targeted cancer therapy Tomography Treatment Outcome Treatments in Oncology Tumors
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Beschreibung
Zusammenfassung:	Sixteen patients with mismatch repair–deficient, locally advanced rectal cancer were enrolled in a pilot study in which 6 months of neoadjuvant anti–PD-1 therapy was to be followed by surgical resection. Twelve patients have completed treatment and have had at least 6 months of follow-up; all 12 had a clinical complete response. All imaging tests and biopsies have shown no viable tumor.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMoa2201445