Eicosapentaenoic acid (EPA) activates PPARγ signaling leading to cell cycle exit, lipid accumulation, and autophagy in human meibomian gland epithelial cells (hMGEC)

The purpose of this study was to access the ability of the natural PPAR agonist, eicosapentaenoic acid (EPA), to activate PPAR gamma (γ) signaling leading to meibocyte differentiation in human meibomian gland epithelial cell (hMGEC). HMGEC were exposed to EPA, alone and in combination with the speci...

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Veröffentlicht in:	The ocular surface 2020-07, Vol.18 (3), p.427-437
Hauptverfasser:	Kim, Sun Woong, Rho, Chang Rae, Kim, Jinseor, Xie, Yilu, Prince, Richard C., Mustafa, Khawla, Potma, Eric O., Brown, Donald J., Jester, James V.
Format:	Artikel
Sprache:	eng
Schlagworte:	Autophagy Cell Cycle Cell cycle exit Eicosapentaenoic Acid - pharmacology Epithelial Cells Human meibomian gland epithelial cell Humans Meibocyte Meibomian Glands PPAR gamma PPARγ
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