Reduced T-cell response following a third dose of SARS-CoV-2 vaccine in infection-naïve people living with HIV

•People living with HIV show similar humoral immune responses towards the third dose of SARS-CoV-2 vaccine compared to HIV-negative individuals.•People living with HIV with no prior SARS-CoV-2 infection show reduced T-cell response towards the third dose of SARS-CoV-2 vaccine compared to HIV-negativ...

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Veröffentlicht in:	The Journal of infection 2022-12, Vol.85 (6), p.702-769
Hauptverfasser:	Moussaoui, Majdouline El, Desmecht, Salomé, Tashkeev, Aleksandr, Lambert, Nicolas, Maes, Nathalie, Braghini, Joachim, Marechal, Nicole, Quintana, Céline, Briquet, Karine, Gofflot, Stéphanie, Toussaint, Françoise, Hayette, Marie-Pierre, Vermeersch, Pieter, Lutteri, Laurence, Grégoire, Céline, Beguin, Yves, Rahmouni, Souad, Moutschen, Michel, Desmecht, Daniel, Darcis, Gilles
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Viral Antibody responses Breakthrough infection Cellular COVID-19 - prevention & control COVID-19 vaccine COVID-19 Vaccines HIV HIV Infections - complications Human health sciences Humans Humoral Immune response Immunologie & maladie infectieuse Immunology & infectious disease Infectious Diseases Letter to the Editor Microbiology (medical) Neutralisation Omicron People living with HIV SARS-CoV-2 SARS-CoV-2 mRNA vaccine Sciences de la santé humaine T-Lymphocytes Third dose
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Beschreibung
Zusammenfassung:	•People living with HIV show similar humoral immune responses towards the third dose of SARS-CoV-2 vaccine compared to HIV-negative individuals.•People living with HIV with no prior SARS-CoV-2 infection show reduced T-cell response towards the third dose of SARS-CoV-2 vaccine compared to HIV-negative individuals.•Hybrid immunity induces similar T-cell responses between people living with HIV and HIV-negative individuals.
ISSN:	0163-4453 1532-2742 1532-2742
DOI:	10.1016/j.jinf.2022.09.006