Antiretroviral therapy initiation within 7 and 8–30 days post-HIV diagnosis demonstrates similar benefits in resource-limited settings

We estimated the optimum time to initiate antiretroviral therapy (ART) in a retrospective observational cohort. We observed that ART initiation 7 days or less ( n  = 817) and 8–30 days ( n  = 1009) were the most important factors with viral suppression, and had similar viral suppression rate, CD4 +...

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Veröffentlicht in:AIDS (London) 2022-10, Vol.36 (12), p.1741-1743
Hauptverfasser: Zhao, Bin, Ding, Haibo, Song, Wei, Kang, Mingming, Dong, Xue, Li, Xin, Wang, Lu, Liu, Jianmin, Chu, Zhenxing, Wang, Lin, Tian, Wen, Qiu, Yu, Shang, Hong, Han, Xiaoxu
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Sprache:eng
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Zusammenfassung:We estimated the optimum time to initiate antiretroviral therapy (ART) in a retrospective observational cohort. We observed that ART initiation 7 days or less ( n  = 817) and 8–30 days ( n  = 1009) were the most important factors with viral suppression, and had similar viral suppression rate, CD4 + T-cell count increase and fractions of individuals with links at least 4 and individuals linked to recent HIV infection in HIV molecular networks. This study provides real-world evidence on the benefits of rapid ART initiation in resource-limited setting.
ISSN:0269-9370
1473-5571
DOI:10.1097/QAD.0000000000003327