Cytokine responses in non-lesional psoriatic skin as clinical predictor to anti-TNF agents

Cytokine responses in non-lesional psoriatic skin as clinical predictor to anti-TNF agents

Enrichment of cytokine signatures in non-lesional psoriatic skin, prior to treatment, exhibits associations with future PASI improvement, and we illustrate the feasibility of integrating cytokine signals with transcriptomic data for drug response prediction in psoriasis.

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Veröffentlicht in:Journal of allergy and clinical immunology 2021-07, Vol.149 (2), p.640-649.e5
Hauptverfasser: Tsoi, Lam C., Patrick, Matthew T., Shuai, Shao, Sarkar, Mrinal K., Chi, Sunyi, Ruffino, Bethany, Billi, Allison C., Xing, Xianying, Uppala, Ranjitha, Zang, Cheng, Fullmer, Joseph, He, Zhi, Maverakis, Emanual, Mehta, Nehal N., White, Bethany E Perez, Getsios, Spiro, Helfrich, Yolanda, Voorhees, John J., Kahlenberg, J. Michelle, Weidinger, Stephan, Gudjonsson, Johann E
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Sprache:eng
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Zusammenfassung:Enrichment of cytokine signatures in non-lesional psoriatic skin, prior to treatment, exhibits associations with future PASI improvement, and we illustrate the feasibility of integrating cytokine signals with transcriptomic data for drug response prediction in psoriasis.
ISSN:0091-6749
1097-6825
DOI:10.1016/j.jaci.2021.07.024