Parvimonas micra promotes colorectal tumorigenesis and is associated with prognosis of colorectal cancer patients

Large-scale fecal shotgun metagenomic sequencing revealed the high abundance of Parvimonas micra in colorectal cancer (CRC) patients. We investigated the role and clinical significance of P. micra in colorectal tumorigenesis. The abundance of P. micra was examined in 309 fecal samples and 165 colon...

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Veröffentlicht in:	Oncogene 2022-09, Vol.41 (36), p.4200-4210
Hauptverfasser:	Zhao, Liuyang, Zhang, Xiang, Zhou, Yunfei, Fu, Kaili, Lau, Harry Cheuk-Hay, Chun, Tommy Wai-Yiu, Cheung, Alvin Ho-Kwan, Coker, Olabisi Oluwabukola, Wei, Hong, Wu, William Ka-Kei, Wong, Sunny Hei, Sung, Joseph Jao-Yiu, To, Ka Fai, Yu, Jun
Format:	Artikel
Sprache:	eng
Schlagworte:	13/51 631/67/1504/1885 64/60 692/53/2422 82/80 96/31 Angiogenesis Animal models Animals Apoptosis Biopsy Carcinogenesis - genetics CD4 antigen Cell Biology Cell differentiation Cell Proliferation Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - pathology Feces Firmicutes Gene Expression Regulation, Neoplastic Germfree Helper cells Human Genetics Humans Interleukin 17 Interleukin 22 Interleukin 23 Interleukin-17 - metabolism Internal Medicine Invasiveness Lymphocytes T Medical prognosis Medicine Medicine & Public Health Metagenomics Metastases Mice Multivariate analysis Oncology Parvimonas micra Patients Phenotypes Phreatodrobia micra Risk factors Signal transduction Tumorigenesis Wnt protein
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Zusammenfassung:	Large-scale fecal shotgun metagenomic sequencing revealed the high abundance of Parvimonas micra in colorectal cancer (CRC) patients. We investigated the role and clinical significance of P. micra in colorectal tumorigenesis. The abundance of P. micra was examined in 309 fecal samples and 165 colon biopsy tissues of CRC patients and healthy subjects. P. micra was significantly enriched in fecal samples from 128 CRC patients compared to 181 healthy subjects ( P
ISSN:	0950-9232 1476-5594
DOI:	10.1038/s41388-022-02395-7