Post-vaccination SARS-CoV-2 antibody kinetics and protection duration against Omicron in elderly population

Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 is particularly severe in older individuals because of an impaired immune response.1 The vaccines presently available are less efficacious in older individuals, because of the senescence of their immune systems.2 A recent letter in Journal...

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Veröffentlicht in:	The Journal of infection 2022-12, Vol.85 (6), p.702-769
Hauptverfasser:	Dimeglio, Chloé, Trémeaux, Pauline, Herin, Fabrice, Da-Silva, Isabelle, Porcheron, Marion, Martin-Blondel, Guillaume, Gernigon, Caroline, Chapuy-Regaud, Sabine, Villars, Hélène, Izopet, Jacques
Format:	Artikel
Sprache:	eng
Schlagworte:	Aged Antibodies, Viral COVID-19 - prevention & control Human health and pathology Humans Kinetics Letter to the Editor Life Sciences SARS-CoV-2 Vaccination
Online-Zugang:	Volltext
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Beschreibung
Zusammenfassung:	Coronavirus disease 2019 (COVID-19) caused by the SARS-CoV-2 is particularly severe in older individuals because of an impaired immune response.1 The vaccines presently available are less efficacious in older individuals, because of the senescence of their immune systems.2 A recent letter in Journal of Infection showed the need of a third vaccine dose due to a waning antibody response against new SARS-CoV-2 variants in healthy and immunocompromised individuals.3 In this study, we analysed the protection against Omicron provided by the immune responses of nursing home residents (NHRs) and a population of healthcare workers (HCWs).
ISSN:	0163-4453 1532-2742
DOI:	10.1016/j.jinf.2022.08.040