Overexpression of the RNA polymerase alpha subunit reduces transcription of Bvg-activated virulence genes in Bordetella pertussis

Overexpression of the RNA polymerase alpha subunit in Bordetella pertussis reduces expression of the virulence factor pertussis toxin. Here we show that this reduction is at the level of transcription, is reversed by overexpression of the transcriptional activator BvgA, and is dependent on the C-ter...

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Veröffentlicht in:	Journal of bacteriology 2000-01, Vol.182 (2), p.529-531
Hauptverfasser:	Carbonetti, N H, Romashko, A, Irish, T J
Format:	Artikel
Sprache:	eng
Schlagworte:	Bacterial Proteins - biosynthesis Bacterial Proteins - genetics Bacteriology Bordetella pertussis Bordetella pertussis - genetics Bordetella pertussis - pathogenicity BvgA protein DNA-Directed RNA Polymerases - biosynthesis Escherichia coli Escherichia coli Proteins Genes Genetics and Molecular Biology Microbiology Ribonucleic acid RNA Structure-Activity Relationship Transcription Factors - biosynthesis Transcription Factors - genetics Transcription, Genetic
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Beschreibung
Zusammenfassung:	Overexpression of the RNA polymerase alpha subunit in Bordetella pertussis reduces expression of the virulence factor pertussis toxin. Here we show that this reduction is at the level of transcription, is reversed by overexpression of the transcriptional activator BvgA, and is dependent on the C-terminal domain of alpha.
ISSN:	0021-9193 1098-5530
DOI:	10.1128/JB.182.2.529-531.2000