Antipsychotics function as epigenetic age regulators in human neuroblastoma cells

Recent epigenetic age studies suggested accelerated aging in schizophrenia. Although antipsychotics may modulate epigenetic age, direct estimation of their roles was impeded when tissues derived from patients were used for analysis. By using a cellular model, we found that antipsychotics generally w...

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Veröffentlicht in:	NPJ schizophrenia 2022-08, Vol.8 (1), p.69-69, Article 69
Hauptverfasser:	Du, Jianbin, Nakachi, Yutaka, Fujii, Ayaka, Fujii, Shinya, Bundo, Miki, Iwamoto, Kazuya
Format:	Artikel
Sprache:	eng
Schlagworte:	631/378/2583 692/699/476/1799 Age Aging Antipsychotics Bipolar disorder Brain Brief Communication Cognitive Psychology Datasets DNA methylation Dopamine Drug dosages Epigenetics Medicine Medicine & Public Health Neuroblastoma Neurology Neurosciences Psychiatry Psychotropic drugs Schizophrenia
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Zusammenfassung:	Recent epigenetic age studies suggested accelerated aging in schizophrenia. Although antipsychotics may modulate epigenetic age, direct estimation of their roles was impeded when tissues derived from patients were used for analysis. By using a cellular model, we found that antipsychotics generally worked as epigenetic age regulators in vitro.
ISSN:	2754-6993 2754-6993 2334-265X
DOI:	10.1038/s41537-022-00277-1