Singular insights into the immunology of SARS-CoV-2 infection

Gaining a better understanding of the immune cell subsets and molecular factors associated with protective or pathological immunity against SARS-CoV-2 could aid the development of vaccines and therapeutics for coronavirus disease (COVID-19). Single-cell technologies, such as flow cytometry, mass cytometry, single-cell transcriptomics and single-cell multiomic profiling, offer considerable promise in dissecting the heterogeneity of immune responses among individual cells and uncovering the molecular mechanisms of COVID-19 pathogenesis. Particularly noteworthy single-cell immune profiling studies have identified innate and adaptive immune cell subsets that correlate with COVID-19 disease severity, as well as immunological factors/pathways of potential relevance to the development of vaccines and treatments for COVID-19. To facilitate integrative studies and meta-analyses, we provide to the scientific research community in download-ready, standardized form 21 published single-cell sequencing datasets (over 3.2 million cells in total), as well as an interactive visualization portal for data exploration.