HAlign 3: Fast Multiple Alignment of Ultra-Large Numbers of Similar DNA/RNA Sequences

HAlign 3: Fast Multiple Alignment of Ultra-Large Numbers of Similar DNA/RNA Sequences

Abstract HAlign is a cross-platform program that performs multiple sequence alignments based on the center star strategy. Here we present two major updates of HAlign 3, which helped improve the time efficiency and the alignment quality, and made HAlign 3 a specialized program to process ultra-large...

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Veröffentlicht in:Molecular biology and evolution 2022-08, Vol.39 (8)
Hauptverfasser: Tang, Furong, Chao, Jiannan, Wei, Yanming, Yang, Fenglong, Zhai, Yixiao, Xu, Lei, Zou, Quan
Format: Artikel
Sprache:eng
Schlagworte:
Genomes
Genomics
Resources
Statistics
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Zusammenfassung:Abstract HAlign is a cross-platform program that performs multiple sequence alignments based on the center star strategy. Here we present two major updates of HAlign 3, which helped improve the time efficiency and the alignment quality, and made HAlign 3 a specialized program to process ultra-large numbers of similar DNA/RNA sequences, such as closely related viral or prokaryotic genomes. HAlign 3 can be easily installed via the Anaconda and Java release package on macOS, Linux, Windows subsystem for Linux, and Windows systems, and the source code is available on GitHub (https://github.com/malabz/HAlign-3).
ISSN:0737-4038
1537-1719
DOI:10.1093/molbev/msac166