Discovery of the Anticancer Activity for Lung and Gastric Cancer of a Brominated Coelenteramine Analog

Cancer is still a challenging disease to treat, both in terms of harmful side effects and therapeutic efficiency of the available treatments. Herein, to develop new therapeutic molecules, we have investigated the anticancer activity of halogenated derivatives of different components of the biolumine...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:International journal of molecular sciences 2022-07, Vol.23 (15), p.8271
Hauptverfasser: González-Berdullas, Patricia, Pereira, Renato B., Teixeira, Cláudia, Silva, José Pedro, Magalhães, Carla M., Rodríguez-Borges, José E., Pereira, David M., Esteves da Silva, Joaquim C. G., Pinto da Silva, Luís
Format: Artikel
Sprache:eng
Schlagworte:
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
container_end_page
container_issue 15
container_start_page 8271
container_title International journal of molecular sciences
container_volume 23
creator González-Berdullas, Patricia
Pereira, Renato B.
Teixeira, Cláudia
Silva, José Pedro
Magalhães, Carla M.
Rodríguez-Borges, José E.
Pereira, David M.
Esteves da Silva, Joaquim C. G.
Pinto da Silva, Luís
description Cancer is still a challenging disease to treat, both in terms of harmful side effects and therapeutic efficiency of the available treatments. Herein, to develop new therapeutic molecules, we have investigated the anticancer activity of halogenated derivatives of different components of the bioluminescent system of marine Coelenterazine: Coelenterazine (Clz) itself, Coelenteramide (Clmd), and Coelenteramine (Clm). We have found that Clz derivatives possess variable anticancer activity toward gastric and lung cancer. Interestingly, we also found that both brominated Clmd (Br-Clmd) and Clm (Br-Clm) were the most potent anticancer compounds toward these cell lines, with this being the first report of the anticancer potential of these types of molecules. Interestingly, Br-Clm possessed some safety profile towards noncancer cells. Further evaluation revealed that the latter compound induced cell death via apoptosis, with evidence for crosstalk between intrinsic and extrinsic pathways. Finally, a thorough exploration of the chemical space of the studied Br-Clm helped identify the structural features responsible for its observed anticancer activity. In conclusion, a new type of compounds with anticancer activity toward gastric and lung cancer was reported and characterized, which showed interesting properties to be considered as a starting point for future optimizations towards obtaining suitable chemotherapeutic agents.
doi_str_mv 10.3390/ijms23158271
format Article
fullrecord <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9368541</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2702188609</sourcerecordid><originalsourceid>FETCH-LOGICAL-c416t-de145a2d85064730f0429f8c7bf975a5807d11f0c4a809aed594074c4aeefb063</originalsourceid><addsrcrecordid>eNpdkU9vEzEQxS0EoqVw4wNY4sKBwPjfrn1BSgMUpEhc4Gw53nHqaHddbG-kfHtcUqHCyeOZn5_e-BHymsF7IQx8iIepcMGU5j17Qi6Z5HwF0PVPH9UX5EUpBwAuuDLPyYVQRikJ3SUJn2Lx6Yj5RFOg9Rbpeq7Ru9ljpmtf4zHWEw0p0-0y76mbB3rjSs3R080Zas8cvc5pirOrONBNwhHnitm1zr2cG9P-JXkW3Fjw1cN5RX5--fxj83W1_X7zbbPerrxkXV0NyKRyfNAKOtkLCCC5Cdr3u2B65ZSGfmAsgJdOg3E4KCOhl-2KGHbQiSvy8ax7t-wmHHwzkt1o73KcXD7Z5KL9dzLHW7tPR2tEp5VkTeDtg0BOvxYs1U7tg3Ac3YxpKZb3wJnWHZiGvvkPPaQlt3X_UM2W1KAb9e5M-ZxKyRj-mmFg7wO0jwMUvwG7So1X</addsrcrecordid><sourcetype>Open Access Repository</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2700744808</pqid></control><display><type>article</type><title>Discovery of the Anticancer Activity for Lung and Gastric Cancer of a Brominated Coelenteramine Analog</title><source>Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals</source><source>MDPI - Multidisciplinary Digital Publishing Institute</source><source>PubMed Central</source><creator>González-Berdullas, Patricia ; Pereira, Renato B. ; Teixeira, Cláudia ; Silva, José Pedro ; Magalhães, Carla M. ; Rodríguez-Borges, José E. ; Pereira, David M. ; Esteves da Silva, Joaquim C. G. ; Pinto da Silva, Luís</creator><creatorcontrib>González-Berdullas, Patricia ; Pereira, Renato B. ; Teixeira, Cláudia ; Silva, José Pedro ; Magalhães, Carla M. ; Rodríguez-Borges, José E. ; Pereira, David M. ; Esteves da Silva, Joaquim C. G. ; Pinto da Silva, Luís</creatorcontrib><description>Cancer is still a challenging disease to treat, both in terms of harmful side effects and therapeutic efficiency of the available treatments. Herein, to develop new therapeutic molecules, we have investigated the anticancer activity of halogenated derivatives of different components of the bioluminescent system of marine Coelenterazine: Coelenterazine (Clz) itself, Coelenteramide (Clmd), and Coelenteramine (Clm). We have found that Clz derivatives possess variable anticancer activity toward gastric and lung cancer. Interestingly, we also found that both brominated Clmd (Br-Clmd) and Clm (Br-Clm) were the most potent anticancer compounds toward these cell lines, with this being the first report of the anticancer potential of these types of molecules. Interestingly, Br-Clm possessed some safety profile towards noncancer cells. Further evaluation revealed that the latter compound induced cell death via apoptosis, with evidence for crosstalk between intrinsic and extrinsic pathways. Finally, a thorough exploration of the chemical space of the studied Br-Clm helped identify the structural features responsible for its observed anticancer activity. In conclusion, a new type of compounds with anticancer activity toward gastric and lung cancer was reported and characterized, which showed interesting properties to be considered as a starting point for future optimizations towards obtaining suitable chemotherapeutic agents.</description><identifier>ISSN: 1422-0067</identifier><identifier>ISSN: 1661-6596</identifier><identifier>EISSN: 1422-0067</identifier><identifier>DOI: 10.3390/ijms23158271</identifier><identifier>PMID: 35955406</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Antitumor activity ; Apoptosis ; Bromination ; Cancer therapies ; Cell death ; Chemotherapy ; Crosstalk ; Cytotoxicity ; Decomposition ; Gastric cancer ; Investigations ; Light ; Lung cancer ; Prostate ; Toxicity ; Tumors</subject><ispartof>International journal of molecular sciences, 2022-07, Vol.23 (15), p.8271</ispartof><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c416t-de145a2d85064730f0429f8c7bf975a5807d11f0c4a809aed594074c4aeefb063</citedby><cites>FETCH-LOGICAL-c416t-de145a2d85064730f0429f8c7bf975a5807d11f0c4a809aed594074c4aeefb063</cites><orcidid>0000-0002-9139-090X ; 0000-0003-0384-7592 ; 0000-0001-8500-7364 ; 0000-0002-9152-7865 ; 0000-0001-8478-3441 ; 0000-0002-0138-4929 ; 0000-0002-5647-8455</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368541/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9368541/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,881,27903,27904,53770,53772</link.rule.ids></links><search><creatorcontrib>González-Berdullas, Patricia</creatorcontrib><creatorcontrib>Pereira, Renato B.</creatorcontrib><creatorcontrib>Teixeira, Cláudia</creatorcontrib><creatorcontrib>Silva, José Pedro</creatorcontrib><creatorcontrib>Magalhães, Carla M.</creatorcontrib><creatorcontrib>Rodríguez-Borges, José E.</creatorcontrib><creatorcontrib>Pereira, David M.</creatorcontrib><creatorcontrib>Esteves da Silva, Joaquim C. G.</creatorcontrib><creatorcontrib>Pinto da Silva, Luís</creatorcontrib><title>Discovery of the Anticancer Activity for Lung and Gastric Cancer of a Brominated Coelenteramine Analog</title><title>International journal of molecular sciences</title><description>Cancer is still a challenging disease to treat, both in terms of harmful side effects and therapeutic efficiency of the available treatments. Herein, to develop new therapeutic molecules, we have investigated the anticancer activity of halogenated derivatives of different components of the bioluminescent system of marine Coelenterazine: Coelenterazine (Clz) itself, Coelenteramide (Clmd), and Coelenteramine (Clm). We have found that Clz derivatives possess variable anticancer activity toward gastric and lung cancer. Interestingly, we also found that both brominated Clmd (Br-Clmd) and Clm (Br-Clm) were the most potent anticancer compounds toward these cell lines, with this being the first report of the anticancer potential of these types of molecules. Interestingly, Br-Clm possessed some safety profile towards noncancer cells. Further evaluation revealed that the latter compound induced cell death via apoptosis, with evidence for crosstalk between intrinsic and extrinsic pathways. Finally, a thorough exploration of the chemical space of the studied Br-Clm helped identify the structural features responsible for its observed anticancer activity. In conclusion, a new type of compounds with anticancer activity toward gastric and lung cancer was reported and characterized, which showed interesting properties to be considered as a starting point for future optimizations towards obtaining suitable chemotherapeutic agents.</description><subject>Antitumor activity</subject><subject>Apoptosis</subject><subject>Bromination</subject><subject>Cancer therapies</subject><subject>Cell death</subject><subject>Chemotherapy</subject><subject>Crosstalk</subject><subject>Cytotoxicity</subject><subject>Decomposition</subject><subject>Gastric cancer</subject><subject>Investigations</subject><subject>Light</subject><subject>Lung cancer</subject><subject>Prostate</subject><subject>Toxicity</subject><subject>Tumors</subject><issn>1422-0067</issn><issn>1661-6596</issn><issn>1422-0067</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>8G5</sourceid><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><sourceid>GNUQQ</sourceid><sourceid>GUQSH</sourceid><sourceid>M2O</sourceid><recordid>eNpdkU9vEzEQxS0EoqVw4wNY4sKBwPjfrn1BSgMUpEhc4Gw53nHqaHddbG-kfHtcUqHCyeOZn5_e-BHymsF7IQx8iIepcMGU5j17Qi6Z5HwF0PVPH9UX5EUpBwAuuDLPyYVQRikJ3SUJn2Lx6Yj5RFOg9Rbpeq7Ru9ljpmtf4zHWEw0p0-0y76mbB3rjSs3R080Zas8cvc5pirOrONBNwhHnitm1zr2cG9P-JXkW3Fjw1cN5RX5--fxj83W1_X7zbbPerrxkXV0NyKRyfNAKOtkLCCC5Cdr3u2B65ZSGfmAsgJdOg3E4KCOhl-2KGHbQiSvy8ax7t-wmHHwzkt1o73KcXD7Z5KL9dzLHW7tPR2tEp5VkTeDtg0BOvxYs1U7tg3Ac3YxpKZb3wJnWHZiGvvkPPaQlt3X_UM2W1KAb9e5M-ZxKyRj-mmFg7wO0jwMUvwG7So1X</recordid><startdate>20220727</startdate><enddate>20220727</enddate><creator>González-Berdullas, Patricia</creator><creator>Pereira, Renato B.</creator><creator>Teixeira, Cláudia</creator><creator>Silva, José Pedro</creator><creator>Magalhães, Carla M.</creator><creator>Rodríguez-Borges, José E.</creator><creator>Pereira, David M.</creator><creator>Esteves da Silva, Joaquim C. G.</creator><creator>Pinto da Silva, Luís</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>8G5</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>GUQSH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>M2O</scope><scope>MBDVC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>Q9U</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0002-9139-090X</orcidid><orcidid>https://orcid.org/0000-0003-0384-7592</orcidid><orcidid>https://orcid.org/0000-0001-8500-7364</orcidid><orcidid>https://orcid.org/0000-0002-9152-7865</orcidid><orcidid>https://orcid.org/0000-0001-8478-3441</orcidid><orcidid>https://orcid.org/0000-0002-0138-4929</orcidid><orcidid>https://orcid.org/0000-0002-5647-8455</orcidid></search><sort><creationdate>20220727</creationdate><title>Discovery of the Anticancer Activity for Lung and Gastric Cancer of a Brominated Coelenteramine Analog</title><author>González-Berdullas, Patricia ; Pereira, Renato B. ; Teixeira, Cláudia ; Silva, José Pedro ; Magalhães, Carla M. ; Rodríguez-Borges, José E. ; Pereira, David M. ; Esteves da Silva, Joaquim C. G. ; Pinto da Silva, Luís</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c416t-de145a2d85064730f0429f8c7bf975a5807d11f0c4a809aed594074c4aeefb063</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Antitumor activity</topic><topic>Apoptosis</topic><topic>Bromination</topic><topic>Cancer therapies</topic><topic>Cell death</topic><topic>Chemotherapy</topic><topic>Crosstalk</topic><topic>Cytotoxicity</topic><topic>Decomposition</topic><topic>Gastric cancer</topic><topic>Investigations</topic><topic>Light</topic><topic>Lung cancer</topic><topic>Prostate</topic><topic>Toxicity</topic><topic>Tumors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>González-Berdullas, Patricia</creatorcontrib><creatorcontrib>Pereira, Renato B.</creatorcontrib><creatorcontrib>Teixeira, Cláudia</creatorcontrib><creatorcontrib>Silva, José Pedro</creatorcontrib><creatorcontrib>Magalhães, Carla M.</creatorcontrib><creatorcontrib>Rodríguez-Borges, José E.</creatorcontrib><creatorcontrib>Pereira, David M.</creatorcontrib><creatorcontrib>Esteves da Silva, Joaquim C. G.</creatorcontrib><creatorcontrib>Pinto da Silva, Luís</creatorcontrib><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health &amp; Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>Research Library (Alumni Edition)</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central Korea</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>Research Library Prep</collection><collection>ProQuest Health &amp; Medical Complete (Alumni)</collection><collection>Health &amp; Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>Research Library</collection><collection>Research Library (Corporate)</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>ProQuest Central Basic</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of molecular sciences</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>González-Berdullas, Patricia</au><au>Pereira, Renato B.</au><au>Teixeira, Cláudia</au><au>Silva, José Pedro</au><au>Magalhães, Carla M.</au><au>Rodríguez-Borges, José E.</au><au>Pereira, David M.</au><au>Esteves da Silva, Joaquim C. G.</au><au>Pinto da Silva, Luís</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Discovery of the Anticancer Activity for Lung and Gastric Cancer of a Brominated Coelenteramine Analog</atitle><jtitle>International journal of molecular sciences</jtitle><date>2022-07-27</date><risdate>2022</risdate><volume>23</volume><issue>15</issue><spage>8271</spage><pages>8271-</pages><issn>1422-0067</issn><issn>1661-6596</issn><eissn>1422-0067</eissn><abstract>Cancer is still a challenging disease to treat, both in terms of harmful side effects and therapeutic efficiency of the available treatments. Herein, to develop new therapeutic molecules, we have investigated the anticancer activity of halogenated derivatives of different components of the bioluminescent system of marine Coelenterazine: Coelenterazine (Clz) itself, Coelenteramide (Clmd), and Coelenteramine (Clm). We have found that Clz derivatives possess variable anticancer activity toward gastric and lung cancer. Interestingly, we also found that both brominated Clmd (Br-Clmd) and Clm (Br-Clm) were the most potent anticancer compounds toward these cell lines, with this being the first report of the anticancer potential of these types of molecules. Interestingly, Br-Clm possessed some safety profile towards noncancer cells. Further evaluation revealed that the latter compound induced cell death via apoptosis, with evidence for crosstalk between intrinsic and extrinsic pathways. Finally, a thorough exploration of the chemical space of the studied Br-Clm helped identify the structural features responsible for its observed anticancer activity. In conclusion, a new type of compounds with anticancer activity toward gastric and lung cancer was reported and characterized, which showed interesting properties to be considered as a starting point for future optimizations towards obtaining suitable chemotherapeutic agents.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>35955406</pmid><doi>10.3390/ijms23158271</doi><orcidid>https://orcid.org/0000-0002-9139-090X</orcidid><orcidid>https://orcid.org/0000-0003-0384-7592</orcidid><orcidid>https://orcid.org/0000-0001-8500-7364</orcidid><orcidid>https://orcid.org/0000-0002-9152-7865</orcidid><orcidid>https://orcid.org/0000-0001-8478-3441</orcidid><orcidid>https://orcid.org/0000-0002-0138-4929</orcidid><orcidid>https://orcid.org/0000-0002-5647-8455</orcidid><oa>free_for_read</oa></addata></record>
fulltext fulltext
identifier ISSN: 1422-0067
ispartof International journal of molecular sciences, 2022-07, Vol.23 (15), p.8271
issn 1422-0067
1661-6596
1422-0067
language eng
recordid cdi_pubmedcentral_primary_oai_pubmedcentral_nih_gov_9368541
source Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; MDPI - Multidisciplinary Digital Publishing Institute; PubMed Central
subjects Antitumor activity
Apoptosis
Bromination
Cancer therapies
Cell death
Chemotherapy
Crosstalk
Cytotoxicity
Decomposition
Gastric cancer
Investigations
Light
Lung cancer
Prostate
Toxicity
Tumors
title Discovery of the Anticancer Activity for Lung and Gastric Cancer of a Brominated Coelenteramine Analog
url https://sfx.bib-bvb.de/sfx_tum?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-23T08%3A40%3A35IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Discovery%20of%20the%20Anticancer%20Activity%20for%20Lung%20and%20Gastric%20Cancer%20of%20a%20Brominated%20Coelenteramine%20Analog&rft.jtitle=International%20journal%20of%20molecular%20sciences&rft.au=Gonz%C3%A1lez-Berdullas,%20Patricia&rft.date=2022-07-27&rft.volume=23&rft.issue=15&rft.spage=8271&rft.pages=8271-&rft.issn=1422-0067&rft.eissn=1422-0067&rft_id=info:doi/10.3390/ijms23158271&rft_dat=%3Cproquest_pubme%3E2702188609%3C/proquest_pubme%3E%3Curl%3E%3C/url%3E&disable_directlink=true&sfx.directlink=off&sfx.report_link=0&rft_id=info:oai/&rft_pqid=2700744808&rft_id=info:pmid/35955406&rfr_iscdi=true