Association of AMH and AMHR2 gene polymorphisms with ovarian response and pregnancy outcomes in Indian women

Purpose To evaluate the association of single-nucleotide polymorphisms (SNPs) in the anti-Müllerian hormone ( AMH ) and AMH type II receptor ( AMHR2 ) genes with ovarian response and clinical pregnancy outcomes in women undergoing controlled ovarian hyperstimulation. Methods In this prospective study, we genotyped AMH polymorphisms (c. -649 T > C, c. 146 T > G, c. 252 G > A, and c. 303 G > A) in 365 women and AMHR2 polymorphisms (c. -482 A > G, c. 622–6 C > T, c. 4952 G > A, c. 10 A > G) in 80 women undergoing controlled ovarian hyperstimulation for IVF. Results Higher doses of exogenous FSH and lower numbers of preovulatory follicles were noted in women having AMH c. -649 T > C and AMH c. -146 T > G polymorphisms, respectively. Overall, we found that the presence of a polymorphic genotype (homozygous or heterozygous) at positions c. -649 T > C, c. 146 T > G, c. 252 G > A, and c. 303 G > A in the AMH gene was associated with higher doses of FSH for ovulation induction ( p G, c. 622–6 C > T, c. 4952 G > A, and c. 10 A > G) negatively correlate with live birth rate. However, these findings need to be validated by using larger sample size.