Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151

Jejuketomycins A and B, polyketide glycosides with cancer cell migration inhibitory activity from Streptomyces sp. KCB15JA151

Two new polyketide glycosides jejuketomycins A (1) and B (2), were isolated from a culture of Streptomyces sp. KCB15JA151. Their chemical structures including the absolute configurations were determined by detailed analyses of the NMR and HRMS data and ECD calculations and spectral data. Compounds 1...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:RSC advances 2022-08, Vol.12 (35), p.22360-22366
Hauptverfasser: Jang, Jun-Pil, Kim, Gil Soo, Oh, Tae Hoon, Park, Beomcheol, Kim, Minhee, Hwang, Gwi Ja, Lee, Hyeok-Won, Lee, Jin-Gyeom, Hong, Young-Soo, Ahn, Jong Seog, Ko, Sung-Kyun, Jang, Jae-Hyuk
Format: Artikel
Sprache:eng
Schlagworte:
Cancer
Chemistry
Glycosides
NMR
Nuclear magnetic resonance
Toxicity
Wound healing
Online-Zugang:Volltext
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Two new polyketide glycosides jejuketomycins A (1) and B (2), were isolated from a culture of Streptomyces sp. KCB15JA151. Their chemical structures including the absolute configurations were determined by detailed analyses of the NMR and HRMS data and ECD calculations and spectral data. Compounds 1 and 2 possess an unusual 6/6/8 tricyclic ring system. Biological evaluation with the wound healing assay and time-lapse cell tracking analysis revealed that compounds 1 and 2 have significant inhibitory activities against cancer cell migration with low cytotoxicity.
ISSN:2046-2069
2046-2069
DOI:10.1039/d2ra04039e