Label-Free Profiling of up to 200 Single-Cell Proteomes per Day Using a Dual-Column Nanoflow Liquid Chromatography Platform

Single-cell proteomics (SCP) has great potential to advance biomedical research and personalized medicine. The sensitivity of such measurements increases with low-flow separations (

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Bibliographische Detailangaben
Veröffentlicht in:	Analytical chemistry (Washington) 2022-04, Vol.94 (15), p.6017-6025
Hauptverfasser:	Webber, Kei G. I, Truong, Thy, Johnston, S. Madisyn, Zapata, Sebastian E, Liang, Yiran, Davis, Jacob M, Buttars, Alexander D, Smith, Fletcher B, Jones, Hailey E, Mahoney, Arianna C, Carson, Richard H, Nwosu, Andikan J, Heninger, Jacob L, Liyu, Andrey V, Nordin, Gregory P, Zhu, Ying, Kelly, Ryan T
Format:	Artikel
Sprache:	eng
Schlagworte:	cells Chemistry Chromatography Chromatography, Liquid - methods Column chromatography Cycle protein Desalination HeLa Cells Humans INORGANIC, ORGANIC, PHYSICAL, AND ANALYTICAL CHEMISTRY Ionization Leukemia Liquid chromatography mass spectrometry Medical research Peptides Peptides - analysis peptides and proteins Pilot Projects Precision medicine protein identification Proteins Proteome - analysis Proteomes Proteomics proteomics, nanoPOTS Regeneration Subsystems Therapeutic targets Tumor cell lines
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Beschreibung
Zusammenfassung:	Single-cell proteomics (SCP) has great potential to advance biomedical research and personalized medicine. The sensitivity of such measurements increases with low-flow separations (
ISSN:	0003-2700 1520-6882 1520-6882
DOI:	10.1021/acs.analchem.2c00646