Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States
Abstract A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals t...
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| Veröffentlicht in: | Open Forum Infectious Diseases 2022-08, Vol.9 (8), p.ofac377-ofac377 |
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| container_title | Open Forum Infectious Diseases |
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| creator | Matias, Wilfredo R Koshy, Jacob M Nagami, Ellen H Kovac, Victor Moeng, Letumile R Shenoy, Erica S Hooper, David C Madoff, Lawrence C Barshak, Miriam B Johnson, Jennifer A Rowley, Christopher F Julg, Boris Hohmann, Elizabeth L Lazarus, Jacob E |
| description | Abstract
A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals treated with tecovirimat, a pan-Orthopoxvirus inhibitor currently available under an expanded access investigational new drug protocol for monkeypox. |
| doi_str_mv | 10.1093/ofid/ofac377 |
| format | Article |
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A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals treated with tecovirimat, a pan-Orthopoxvirus inhibitor currently available under an expanded access investigational new drug protocol for monkeypox.</description><identifier>ISSN: 2328-8957</identifier><identifier>EISSN: 2328-8957</identifier><identifier>DOI: 10.1093/ofid/ofac377</identifier><identifier>PMID: 35949403</identifier><language>eng</language><publisher>United States: Oxford University Press</publisher><subject>Brief Report ; Care and treatment ; Health aspects ; Hospitals ; Human monkeypox ; Massachusetts ; Smallpox vaccine</subject><ispartof>Open Forum Infectious Diseases, 2022-08, Vol.9 (8), p.ofac377-ofac377</ispartof><rights>The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America. 2022</rights><rights>The Author(s) 2022. Published by Oxford University Press on behalf of Infectious Diseases Society of America.</rights><rights>COPYRIGHT 2022 Oxford University Press</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c549t-ecd6dca327be09969c09c582f479a5d579b20d401ef53dc7a06f9a9e572531a93</citedby><cites>FETCH-LOGICAL-c549t-ecd6dca327be09969c09c582f479a5d579b20d401ef53dc7a06f9a9e572531a93</cites><orcidid>0000-0001-8086-1123 ; 0000-0002-4687-9626 ; 0000-0001-9286-3548</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356679/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9356679/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,1598,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35949403$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Matias, Wilfredo R</creatorcontrib><creatorcontrib>Koshy, Jacob M</creatorcontrib><creatorcontrib>Nagami, Ellen H</creatorcontrib><creatorcontrib>Kovac, Victor</creatorcontrib><creatorcontrib>Moeng, Letumile R</creatorcontrib><creatorcontrib>Shenoy, Erica S</creatorcontrib><creatorcontrib>Hooper, David C</creatorcontrib><creatorcontrib>Madoff, Lawrence C</creatorcontrib><creatorcontrib>Barshak, Miriam B</creatorcontrib><creatorcontrib>Johnson, Jennifer A</creatorcontrib><creatorcontrib>Rowley, Christopher F</creatorcontrib><creatorcontrib>Julg, Boris</creatorcontrib><creatorcontrib>Hohmann, Elizabeth L</creatorcontrib><creatorcontrib>Lazarus, Jacob E</creatorcontrib><title>Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States</title><title>Open Forum Infectious Diseases</title><addtitle>Open Forum Infect Dis</addtitle><description>Abstract
A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals treated with tecovirimat, a pan-Orthopoxvirus inhibitor currently available under an expanded access investigational new drug protocol for monkeypox.</description><subject>Brief Report</subject><subject>Care and treatment</subject><subject>Health aspects</subject><subject>Hospitals</subject><subject>Human monkeypox</subject><subject>Massachusetts</subject><subject>Smallpox vaccine</subject><issn>2328-8957</issn><issn>2328-8957</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>TOX</sourceid><recordid>eNp9kc1rXCEUxaW0NGGaXdfFXbvIpH48n2MXhSE0TSChi0zW4ug1Y_ueTtUXkv--DjMN6aYIV_H-7uEeDkLvKTmjRPHPyQfXirFcylfomHG2mC-UkK9fvI_QSSk_CSGUEkGkeouOuFCd6gg_RrACmx5CDqOp2KeM6wbwKoOpI8SKk8eX02givknxFzxt0-MXvIz4KoYazIBvIQco-CKnEd-YUozdTAVqLaf4riHg8G01Fco79MabocDJ4Z6hu4tvq_PL-fWP71fny-u5FZ2qc7Cud9ZwJtdAlOqVJcqKBfOdVEY4IdWaEdcRCl5wZ6UhvVdGgZBMcGoUn6Gve93ttB7B2WYhm0Fvd_byk04m6H87MWz0fXrQiou-lzuBTweBnH5PUKoeQ7EwDCZCmopmklAiO9qzhp7t0XszgA7Rp6Zo23EwBpsi-ND-l1L2tJOsLThDp_sBm1MpGfzzXpToXZp6l6Y-pNnwDy-9PMN_s2vAxz2Qpu3_pf4AuVarHQ</recordid><startdate>20220801</startdate><enddate>20220801</enddate><creator>Matias, Wilfredo R</creator><creator>Koshy, Jacob M</creator><creator>Nagami, Ellen H</creator><creator>Kovac, Victor</creator><creator>Moeng, Letumile R</creator><creator>Shenoy, Erica S</creator><creator>Hooper, David C</creator><creator>Madoff, Lawrence C</creator><creator>Barshak, Miriam B</creator><creator>Johnson, Jennifer A</creator><creator>Rowley, Christopher F</creator><creator>Julg, Boris</creator><creator>Hohmann, Elizabeth L</creator><creator>Lazarus, Jacob E</creator><general>Oxford University Press</general><scope>TOX</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>IAO</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0001-8086-1123</orcidid><orcidid>https://orcid.org/0000-0002-4687-9626</orcidid><orcidid>https://orcid.org/0000-0001-9286-3548</orcidid></search><sort><creationdate>20220801</creationdate><title>Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States</title><author>Matias, Wilfredo R ; Koshy, Jacob M ; Nagami, Ellen H ; Kovac, Victor ; Moeng, Letumile R ; Shenoy, Erica S ; Hooper, David C ; Madoff, Lawrence C ; Barshak, Miriam B ; Johnson, Jennifer A ; Rowley, Christopher F ; Julg, Boris ; Hohmann, Elizabeth L ; Lazarus, Jacob E</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c549t-ecd6dca327be09969c09c582f479a5d579b20d401ef53dc7a06f9a9e572531a93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Brief Report</topic><topic>Care and treatment</topic><topic>Health aspects</topic><topic>Hospitals</topic><topic>Human monkeypox</topic><topic>Massachusetts</topic><topic>Smallpox vaccine</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Matias, Wilfredo R</creatorcontrib><creatorcontrib>Koshy, Jacob M</creatorcontrib><creatorcontrib>Nagami, Ellen H</creatorcontrib><creatorcontrib>Kovac, Victor</creatorcontrib><creatorcontrib>Moeng, Letumile R</creatorcontrib><creatorcontrib>Shenoy, Erica S</creatorcontrib><creatorcontrib>Hooper, David C</creatorcontrib><creatorcontrib>Madoff, Lawrence C</creatorcontrib><creatorcontrib>Barshak, Miriam B</creatorcontrib><creatorcontrib>Johnson, Jennifer A</creatorcontrib><creatorcontrib>Rowley, Christopher F</creatorcontrib><creatorcontrib>Julg, Boris</creatorcontrib><creatorcontrib>Hohmann, Elizabeth L</creatorcontrib><creatorcontrib>Lazarus, Jacob E</creatorcontrib><collection>Oxford Journals Open Access Collection</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Gale Academic OneFile</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Open Forum Infectious Diseases</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Matias, Wilfredo R</au><au>Koshy, Jacob M</au><au>Nagami, Ellen H</au><au>Kovac, Victor</au><au>Moeng, Letumile R</au><au>Shenoy, Erica S</au><au>Hooper, David C</au><au>Madoff, Lawrence C</au><au>Barshak, Miriam B</au><au>Johnson, Jennifer A</au><au>Rowley, Christopher F</au><au>Julg, Boris</au><au>Hohmann, Elizabeth L</au><au>Lazarus, Jacob E</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States</atitle><jtitle>Open Forum Infectious Diseases</jtitle><addtitle>Open Forum Infect Dis</addtitle><date>2022-08-01</date><risdate>2022</risdate><volume>9</volume><issue>8</issue><spage>ofac377</spage><epage>ofac377</epage><pages>ofac377-ofac377</pages><issn>2328-8957</issn><eissn>2328-8957</eissn><abstract>Abstract
A large, ongoing multicountry outbreak of human monkeypox has the potential to cause considerable morbidity and mortality. Therapeutics for the treatment of smallpox, a related Orthopoxvirus, may be used and affect the natural history of monkeypox. We present 3 patients from our hospitals treated with tecovirimat, a pan-Orthopoxvirus inhibitor currently available under an expanded access investigational new drug protocol for monkeypox.</abstract><cop>United States</cop><pub>Oxford University Press</pub><pmid>35949403</pmid><doi>10.1093/ofid/ofac377</doi><orcidid>https://orcid.org/0000-0001-8086-1123</orcidid><orcidid>https://orcid.org/0000-0002-4687-9626</orcidid><orcidid>https://orcid.org/0000-0001-9286-3548</orcidid><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 2328-8957 |
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| source | Oxford Journals Open Access Collection; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central |
| subjects | Brief Report Care and treatment Health aspects Hospitals Human monkeypox Massachusetts Smallpox vaccine |
| title | Tecovirimat for the Treatment of Human Monkeypox: An Initial Series From Massachusetts, United States |
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