Overview of Hydroxychloroquine and Remdesivir on severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2)

The novel severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) caused the ongoing pandemic named COVID‐19 which causes a serious emergency on public health hazards of international concern. In the face of a critical medical emergency, repositioning of drugs is one of the most authentic options to design an adequate treatment for infected patients immediately. In this strategy, Remdesivir (Veklury), Hydroxychloroquine appears to be the drug of choice and garnered unprecedented attention as potential therapeutic agents against the pandemic realized worldwide due to SARS‐CoV‐2 infection. These are the breathtaking instances of possible repositioning of drugs, whose pharmacokinetics and optimal dosage are familiar. In this review, we provide an overview of these medications, their synthesis, and the possible mechanism of action against SARS‐CoV‐2. Comprehensive overview on synthesis and mode of actions of antimalarial and antiviral drugs (Remdesivir, Chloroquine, and Hydroxychloroquine) have been furnished to contribute toward the drug repositioning for treatment of severe acute respiratory syndrome coronavirus 2 infection.