Different human papillomavirus types share early natural history transitions in immunocompetent women
Necessary stages of cervical carcinogenesis include acquisition of a carcinogenic human papillomavirus (HPV) type, persistence associated with the development of precancerous lesions, and invasion. Using prospective data from immunocompetent women in the Guanacaste HPV Natural History Study (NHS), t...
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| Veröffentlicht in: | International journal of cancer 2022-09, Vol.151 (6), p.920-929 |
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| creator | Adebamowo, Sally N. Befano, Brian Cheung, Li C. Rodriguez, Ana Cecilia Demarco, Maria Rydzak, Greg Chen, Xiaojian Porras, Carolina Herrero, Rolando Kim, Jane J. Castle, Philip E. Wentzensen, Nicolas Kreimer, Aimée R. Schiffman, Mark Campos, Nicole G. |
| description | Necessary stages of cervical carcinogenesis include acquisition of a carcinogenic human papillomavirus (HPV) type, persistence associated with the development of precancerous lesions, and invasion. Using prospective data from immunocompetent women in the Guanacaste HPV Natural History Study (NHS), the ASCUS‐LSIL Triage Study (ALTS) and the Costa Rica HPV Vaccine Trial (CVT), we compared the early natural history of HPV types to inform transition probabilities for health decision models. We excluded women with evidence of high‐grade cervical abnormalities at any point during follow‐up and restricted the analysis to incident infections in all women and prevalent infections in young women (aged |
| doi_str_mv | 10.1002/ijc.34128 |
| format | Article |
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Using prospective data from immunocompetent women in the Guanacaste HPV Natural History Study (NHS), the ASCUS‐LSIL Triage Study (ALTS) and the Costa Rica HPV Vaccine Trial (CVT), we compared the early natural history of HPV types to inform transition probabilities for health decision models. We excluded women with evidence of high‐grade cervical abnormalities at any point during follow‐up and restricted the analysis to incident infections in all women and prevalent infections in young women (aged <30 years). We used survival approaches accounting for interval‐censoring to estimate the time to clearance distribution for 20 529 HPV infections (64% were incident and 51% were carcinogenic). Time to clearance was similar across HPV types and risk classes (HPV16, HPV18/45, HPV31/33/35/52/58, HPV 39/51/56/59 and noncarcinogenic HPV types); and by age group (18‐29, 30‐44 and 45‐54 years), among carcinogenic and noncarcinogenic infections. Similar time to clearance across HPV types suggests that relative prevalence can predict relative incidence. We confirmed that there was a uniform linear association between incident and prevalent infections for all HPV types within each study cohort. In the absence of progression to precancer, we observed similar time to clearance for incident infections across HPV types and risk classes. A singular clearance function for incident HPV infections has important implications for the refinement of microsimulation models used to evaluate the cost‐effectiveness of novel prevention technologies.</description><identifier>ISSN: 0020-7136</identifier><identifier>ISSN: 1097-0215</identifier><identifier>EISSN: 1097-0215</identifier><identifier>DOI: 10.1002/ijc.34128</identifier><identifier>PMID: 35603904</identifier><language>eng</language><publisher>Hoboken, USA: John Wiley & Sons, Inc</publisher><subject>Alphapapillomavirus ; Cancer ; Carcinogenesis ; Cervical cancer ; Cervix ; early natural history of HPV ; Female ; HPV clearance ; HPV incidence ; HPV prevalence ; Human papillomavirus ; Humans ; Immunocompetence ; Infections ; Medical research ; Natural history ; Papillomaviridae ; Papillomavirus Infections ; Prospective Studies ; Uterine Cervical Dysplasia ; Uterine Cervical Neoplasms - epidemiology ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - prevention & control</subject><ispartof>International journal of cancer, 2022-09, Vol.151 (6), p.920-929</ispartof><rights>Published 2022. This article is a U.S.Government work and is in the public domain in the USA.</rights><rights>2022 UICC</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c4438-b9b30fcefa2c5d646e28c88658d830dba55ed461d3fcae705e56538936a5db8f3</citedby><cites>FETCH-LOGICAL-c4438-b9b30fcefa2c5d646e28c88658d830dba55ed461d3fcae705e56538936a5db8f3</cites><orcidid>0000-0003-4713-2433 ; 0000-0003-1251-0836 ; 0000-0002-0840-4339 ; 0000-0003-3614-210X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://onlinelibrary.wiley.com/doi/pdf/10.1002%2Fijc.34128$$EPDF$$P50$$Gwiley$$H</linktopdf><linktohtml>$$Uhttps://onlinelibrary.wiley.com/doi/full/10.1002%2Fijc.34128$$EHTML$$P50$$Gwiley$$H</linktohtml><link.rule.ids>230,314,776,780,881,1411,27901,27902,45550,45551</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35603904$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Adebamowo, Sally N.</creatorcontrib><creatorcontrib>Befano, Brian</creatorcontrib><creatorcontrib>Cheung, Li C.</creatorcontrib><creatorcontrib>Rodriguez, Ana Cecilia</creatorcontrib><creatorcontrib>Demarco, Maria</creatorcontrib><creatorcontrib>Rydzak, Greg</creatorcontrib><creatorcontrib>Chen, Xiaojian</creatorcontrib><creatorcontrib>Porras, Carolina</creatorcontrib><creatorcontrib>Herrero, Rolando</creatorcontrib><creatorcontrib>Kim, Jane J.</creatorcontrib><creatorcontrib>Castle, Philip E.</creatorcontrib><creatorcontrib>Wentzensen, Nicolas</creatorcontrib><creatorcontrib>Kreimer, Aimée R.</creatorcontrib><creatorcontrib>Schiffman, Mark</creatorcontrib><creatorcontrib>Campos, Nicole G.</creatorcontrib><title>Different human papillomavirus types share early natural history transitions in immunocompetent women</title><title>International journal of cancer</title><addtitle>Int J Cancer</addtitle><description>Necessary stages of cervical carcinogenesis include acquisition of a carcinogenic human papillomavirus (HPV) type, persistence associated with the development of precancerous lesions, and invasion. Using prospective data from immunocompetent women in the Guanacaste HPV Natural History Study (NHS), the ASCUS‐LSIL Triage Study (ALTS) and the Costa Rica HPV Vaccine Trial (CVT), we compared the early natural history of HPV types to inform transition probabilities for health decision models. We excluded women with evidence of high‐grade cervical abnormalities at any point during follow‐up and restricted the analysis to incident infections in all women and prevalent infections in young women (aged <30 years). We used survival approaches accounting for interval‐censoring to estimate the time to clearance distribution for 20 529 HPV infections (64% were incident and 51% were carcinogenic). Time to clearance was similar across HPV types and risk classes (HPV16, HPV18/45, HPV31/33/35/52/58, HPV 39/51/56/59 and noncarcinogenic HPV types); and by age group (18‐29, 30‐44 and 45‐54 years), among carcinogenic and noncarcinogenic infections. Similar time to clearance across HPV types suggests that relative prevalence can predict relative incidence. We confirmed that there was a uniform linear association between incident and prevalent infections for all HPV types within each study cohort. In the absence of progression to precancer, we observed similar time to clearance for incident infections across HPV types and risk classes. A singular clearance function for incident HPV infections has important implications for the refinement of microsimulation models used to evaluate the cost‐effectiveness of novel prevention technologies.</description><subject>Alphapapillomavirus</subject><subject>Cancer</subject><subject>Carcinogenesis</subject><subject>Cervical cancer</subject><subject>Cervix</subject><subject>early natural history of HPV</subject><subject>Female</subject><subject>HPV clearance</subject><subject>HPV incidence</subject><subject>HPV prevalence</subject><subject>Human papillomavirus</subject><subject>Humans</subject><subject>Immunocompetence</subject><subject>Infections</subject><subject>Medical research</subject><subject>Natural history</subject><subject>Papillomaviridae</subject><subject>Papillomavirus Infections</subject><subject>Prospective Studies</subject><subject>Uterine Cervical Dysplasia</subject><subject>Uterine Cervical Neoplasms - epidemiology</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - prevention & control</subject><issn>0020-7136</issn><issn>1097-0215</issn><issn>1097-0215</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp1kU1v1DAURS1ERaeFBX8AWWJDF2n9ETvOBglNCxRVYgNry3FeGI9iO9hJq_x7XKZUUInVW9yjo_t0EXpNyTklhF24vT3nNWXqGdpQ0jYVYVQ8R5uSkaqhXB6jk5z3hFAqSP0CHXMhCW9JvUFw6YYBEoQZ7xZvAp7M5MYxenPr0pLxvE6Qcd6ZBBhMGlcczLwkM-Kdy3NMK56TCdnNLoaMXcDO-yVEG_0E8731LnoIL9HRYMYMrx7uKfr-8erb9nN18_XT9fbDTWXrmquqaztOBguDYVb0spbAlFVKCtUrTvrOCAF9LWnPB2ugIQKEFFy1XBrRd2rgp-j9wTstnYfelgKlqp6S8yatOhqn_02C2-kf8Va3nLWspkXw7kGQ4s8F8qy9yxbG0QSIS9ZMSsWoIlIW9O0TdB-XFMp7hWp5I5USTaHODpRNMecEw2MZSvT9eLqMp3-PV9g3f7d_JP-sVYCLA3DnRlj_b9LXX7YH5S8dvab-</recordid><startdate>20220915</startdate><enddate>20220915</enddate><creator>Adebamowo, Sally N.</creator><creator>Befano, Brian</creator><creator>Cheung, Li C.</creator><creator>Rodriguez, Ana Cecilia</creator><creator>Demarco, Maria</creator><creator>Rydzak, Greg</creator><creator>Chen, Xiaojian</creator><creator>Porras, Carolina</creator><creator>Herrero, Rolando</creator><creator>Kim, Jane J.</creator><creator>Castle, Philip E.</creator><creator>Wentzensen, Nicolas</creator><creator>Kreimer, Aimée R.</creator><creator>Schiffman, Mark</creator><creator>Campos, Nicole G.</creator><general>John Wiley & Sons, Inc</general><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>7TO</scope><scope>7U9</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-4713-2433</orcidid><orcidid>https://orcid.org/0000-0003-1251-0836</orcidid><orcidid>https://orcid.org/0000-0002-0840-4339</orcidid><orcidid>https://orcid.org/0000-0003-3614-210X</orcidid></search><sort><creationdate>20220915</creationdate><title>Different human papillomavirus types share early natural history transitions in immunocompetent women</title><author>Adebamowo, Sally N. ; Befano, Brian ; Cheung, Li C. ; Rodriguez, Ana Cecilia ; Demarco, Maria ; Rydzak, Greg ; Chen, Xiaojian ; Porras, Carolina ; Herrero, Rolando ; Kim, Jane J. ; Castle, Philip E. ; Wentzensen, Nicolas ; Kreimer, Aimée R. ; Schiffman, Mark ; Campos, Nicole G.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4438-b9b30fcefa2c5d646e28c88658d830dba55ed461d3fcae705e56538936a5db8f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Alphapapillomavirus</topic><topic>Cancer</topic><topic>Carcinogenesis</topic><topic>Cervical cancer</topic><topic>Cervix</topic><topic>early natural history of HPV</topic><topic>Female</topic><topic>HPV clearance</topic><topic>HPV incidence</topic><topic>HPV prevalence</topic><topic>Human papillomavirus</topic><topic>Humans</topic><topic>Immunocompetence</topic><topic>Infections</topic><topic>Medical research</topic><topic>Natural history</topic><topic>Papillomaviridae</topic><topic>Papillomavirus Infections</topic><topic>Prospective Studies</topic><topic>Uterine Cervical Dysplasia</topic><topic>Uterine Cervical Neoplasms - epidemiology</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Adebamowo, Sally N.</creatorcontrib><creatorcontrib>Befano, Brian</creatorcontrib><creatorcontrib>Cheung, Li C.</creatorcontrib><creatorcontrib>Rodriguez, Ana Cecilia</creatorcontrib><creatorcontrib>Demarco, Maria</creatorcontrib><creatorcontrib>Rydzak, Greg</creatorcontrib><creatorcontrib>Chen, Xiaojian</creatorcontrib><creatorcontrib>Porras, Carolina</creatorcontrib><creatorcontrib>Herrero, Rolando</creatorcontrib><creatorcontrib>Kim, Jane J.</creatorcontrib><creatorcontrib>Castle, Philip E.</creatorcontrib><creatorcontrib>Wentzensen, Nicolas</creatorcontrib><creatorcontrib>Kreimer, Aimée R.</creatorcontrib><creatorcontrib>Schiffman, Mark</creatorcontrib><creatorcontrib>Campos, Nicole G.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>Oncogenes and Growth Factors Abstracts</collection><collection>Virology and AIDS Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>International journal of cancer</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Adebamowo, Sally N.</au><au>Befano, Brian</au><au>Cheung, Li C.</au><au>Rodriguez, Ana Cecilia</au><au>Demarco, Maria</au><au>Rydzak, Greg</au><au>Chen, Xiaojian</au><au>Porras, Carolina</au><au>Herrero, Rolando</au><au>Kim, Jane J.</au><au>Castle, Philip E.</au><au>Wentzensen, Nicolas</au><au>Kreimer, Aimée R.</au><au>Schiffman, Mark</au><au>Campos, Nicole G.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Different human papillomavirus types share early natural history transitions in immunocompetent women</atitle><jtitle>International journal of cancer</jtitle><addtitle>Int J Cancer</addtitle><date>2022-09-15</date><risdate>2022</risdate><volume>151</volume><issue>6</issue><spage>920</spage><epage>929</epage><pages>920-929</pages><issn>0020-7136</issn><issn>1097-0215</issn><eissn>1097-0215</eissn><abstract>Necessary stages of cervical carcinogenesis include acquisition of a carcinogenic human papillomavirus (HPV) type, persistence associated with the development of precancerous lesions, and invasion. Using prospective data from immunocompetent women in the Guanacaste HPV Natural History Study (NHS), the ASCUS‐LSIL Triage Study (ALTS) and the Costa Rica HPV Vaccine Trial (CVT), we compared the early natural history of HPV types to inform transition probabilities for health decision models. We excluded women with evidence of high‐grade cervical abnormalities at any point during follow‐up and restricted the analysis to incident infections in all women and prevalent infections in young women (aged <30 years). We used survival approaches accounting for interval‐censoring to estimate the time to clearance distribution for 20 529 HPV infections (64% were incident and 51% were carcinogenic). Time to clearance was similar across HPV types and risk classes (HPV16, HPV18/45, HPV31/33/35/52/58, HPV 39/51/56/59 and noncarcinogenic HPV types); and by age group (18‐29, 30‐44 and 45‐54 years), among carcinogenic and noncarcinogenic infections. Similar time to clearance across HPV types suggests that relative prevalence can predict relative incidence. We confirmed that there was a uniform linear association between incident and prevalent infections for all HPV types within each study cohort. In the absence of progression to precancer, we observed similar time to clearance for incident infections across HPV types and risk classes. A singular clearance function for incident HPV infections has important implications for the refinement of microsimulation models used to evaluate the cost‐effectiveness of novel prevention technologies.</abstract><cop>Hoboken, USA</cop><pub>John Wiley & Sons, Inc</pub><pmid>35603904</pmid><doi>10.1002/ijc.34128</doi><tpages>10</tpages><orcidid>https://orcid.org/0000-0003-4713-2433</orcidid><orcidid>https://orcid.org/0000-0003-1251-0836</orcidid><orcidid>https://orcid.org/0000-0002-0840-4339</orcidid><orcidid>https://orcid.org/0000-0003-3614-210X</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Alphapapillomavirus Cancer Carcinogenesis Cervical cancer Cervix early natural history of HPV Female HPV clearance HPV incidence HPV prevalence Human papillomavirus Humans Immunocompetence Infections Medical research Natural history Papillomaviridae Papillomavirus Infections Prospective Studies Uterine Cervical Dysplasia Uterine Cervical Neoplasms - epidemiology Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - prevention & control |
| title | Different human papillomavirus types share early natural history transitions in immunocompetent women |
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