Cardiomyocyte-targeted anti-inflammatory nanotherapeutics against myocardial ischemia reperfusion (IR) injury

Myocardial ischemia reperfusion (IR) injury is closely related to the overwhelming inflammation in the myocardium. Herein, cardiomyocyte-targeted nanotherapeutics were developed for the reactive oxygen species (ROS)-ultrasensitive co-delivery of dexamethasone (Dex) and RAGE small interfering RNA (si...

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Veröffentlicht in:	Nano research 2022, Vol.15 (10), p.9125-9134
Hauptverfasser:	Lan, Min, Hou, Mengying, Yan, Jing, Deng, Qiurong, Zhao, Ziyin, Lv, Shixian, Dang, Juanjuan, Yin, Mengyuan, Ji, Yong, Yin, Lichen
Format:	Artikel
Sprache:	eng
Schlagworte:	Apoptosis Atomic/Molecular Structure and Spectra Biomedicine Biotechnology Cardiomyocytes Cell membranes Chemistry and Materials Science Condensed Matter Physics Dexamethasone Fibrosis Inflammation Injury prevention Intravenous administration Ischemia Materials Science Myocardial ischemia Myocardium Nanoparticles Nanotechnology Nucleic acids Payloads Polyelectrolytes Polyethyleneimine Prostaglandin E2 Reactive oxygen species Reperfusion Research Article Silica siRNA
Online-Zugang:	Volltext
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