Taurine Ameliorates Iron Overload-Induced Hepatocyte Injury via the Bcl-2/VDAC1-Mediated Mitochondrial Apoptosis Pathway

Iron overload can induce reactive oxygen species (ROS) burst and liver damage. Taurine can reduce ROS production and ameliorate liver injury caused by iron overload; however, the underlying molecular mechanism remains elusive. Herein, L02 cells treated with 120 μM iron dextran for 48 h showed marked...

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Veröffentlicht in:	Oxidative medicine and cellular longevity 2022, Vol.2022, p.4135752-14
Hauptverfasser:	Feng, Xiaoyu, Hu, Wenfeng, Hong, Yujiao, Ruan, Linlin, Hu, Yueben, Liu, Dan
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Apoptosis Biotechnology Cytochrome Flow cytometry Hepatocytes - metabolism Humans Iron Overload - drug therapy Iron Overload - metabolism Lipid peroxidation Lipids Liver Medical prognosis Medical research Membrane Potential, Mitochondrial Mitochondria Mitochondrial Permeability Transition Pore Oxidative Stress Physiology Proteins Reactive oxygen species Reactive Oxygen Species - metabolism Taurine - metabolism Taurine - pharmacology Voltage-Dependent Anion Channel 1 - metabolism
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