Longitudinal survey of humoral and cellular response to SARS-CoV-2 infection in children

Data regarding humoral and cellular response against SARS-CoV-2 in children are scarce. We analysed seroconversion rate, decrease of anti-RBD IgG antibodies over time and T-cell response in paediatric patients who suffered COVID-19. Longitudinal study of paediatric patients COVID-19 diagnosed by pos...

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Veröffentlicht in:	Microbiological research 2022-11, Vol.264, p.127145-127145, Article 127145
Hauptverfasser:	Ruedas-López, Alba, Berzosa-Sánchez, Arantxa, Illán-Ramos, Marta, Callejas-Caballero, Ignacio, Guillén-Martín, Sara, Bodas-Pinedo, Andrés, Rueda-Esteban, Santiago, Pérez-Rodríguez, Olga, Vecino-López, Raquel, Lara, Diego López-de, Infante, Iciar Rodríguez-Avial, Merino-Amador, Paloma, Hoyo, Rafael Sánchez-del, Ramos-Amador, José T.
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies, Viral Cellular response Child Child, Preschool Children COVID-19 Humans Humoral response IgG antibodies Immunoglobulin G Longitudinal Studies SARS-CoV-2
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Zusammenfassung:	Data regarding humoral and cellular response against SARS-CoV-2 in children are scarce. We analysed seroconversion rate, decrease of anti-RBD IgG antibodies over time and T-cell response in paediatric patients who suffered COVID-19. Longitudinal study of paediatric patients COVID-19 diagnosed by positive molecular assay in nasopharyngeal swabs. Blood samples were drawn 1–2 months and 6–7 months after acute infection. Anti-RBD IgG were determined using the Alinity® SARS-CoV-2 IgG II Quant assay (Abbott). Cellular immune response was analysed by T-SPOT® SARS-CoV-2 assay kit (Oxford Immunotec Ltd.). 27/39 (69,2%) patients seroconverted. Despite a significant decrease in antibody levels over time (p
ISSN:	0944-5013 1618-0623
DOI:	10.1016/j.micres.2022.127145