Integrative multi‐omic analysis reveals neurodevelopmental gene dysregulation in CIC‐knockout and IDH1‐mutant cells

Capicua (CIC)'s transcriptional repressor function is implicated in neurodevelopment and in oligodendroglioma (ODG) aetiology. However, CIC's role in these contexts remains obscure, primarily from our currently limited knowledge regarding its biological functions. Moreover, CIC mutations i...

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Veröffentlicht in:The Journal of pathology 2022-03, Vol.256 (3), p.297-309
Hauptverfasser: Lee, Stephen D, Song, Jungeun, LeBlanc, Veronique G, Marra, Marco A
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Sprache:eng
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