Functional variants in cytochrome b5 type A (CYB5A) are enriched in Southwest American Indian individuals and associate with obesity

Functional variants in cytochrome b5 type A (CYB5A) are enriched in Southwest American Indian individuals and associate with obesity

Objective This study aimed to identify genetic variants enriched in Southwest American Indian (SWAI) individuals that associate with BMI. Methods Whole genome sequencing data (n = 296) were used to identify potentially functional variants that are common in SWAI individuals (minor allele frequency ≥...

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Veröffentlicht in:Obesity (Silver Spring, Md.) Md.), 2022-02, Vol.30 (2), p.546-552
Hauptverfasser: Day, Samantha E., Traurig, Michael, Kumar, Pankaj, Piaggi, Paolo, Koroglu, Cigdem, Kobes, Sayuko, Hanson, Robert L., Bogardus, Clifton, Baier, Leslie J.
Format: Artikel
Sprache:eng
Schlagworte:
Age
American Indians or Alaska Natives
Body fat
Body Mass Index
Cytochrome
Cytochromes b5 - genetics
Cytochromes b5 - metabolism
Diabetes
Gene expression
Gene Frequency
Genomes
Haplotypes
Humans
Minority & ethnic groups
Musculoskeletal system
Native North Americans
Obesity
Obesity - genetics
Original
ORIGINAL ARTICLES
Polymorphism, Single Nucleotide
Population
Regression analysis
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Zusammenfassung:Objective This study aimed to identify genetic variants enriched in Southwest American Indian (SWAI) individuals that associate with BMI. Methods Whole genome sequencing data (n = 296) were used to identify potentially functional variants that are common in SWAI individuals (minor allele frequency ≥10%) but rare in other ethnic groups (minor allele frequency 
ISSN:1930-7381
1930-739X
DOI:10.1002/oby.23359