Interferon-γ Release Assays in Children <15 Years of Age

The tuberculin skin test (TST) has been preferred for screening young children for latent tuberculosis infection (LTBI) because of concerns that interferon-γ release assays (IGRAs) may be less sensitive in this high-risk population. In this study, we compared the predictive value of IGRAs to the TST...

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Veröffentlicht in:	Pediatrics (Evanston) 2020-01, Vol.145 (1), p.1
Hauptverfasser:	Ahmed, Amina, Feng, Pei-Jean I, Gaensbauer, James T, Reves, Randall R, Khurana, Renuka, Salcedo, Katya, Punnoose, Rose, Katz, Dolly J
Format:	Artikel
Sprache:	eng
Schlagworte:	Child Child, Preschool Children Disease Progression Female Humans Infant Interferon Interferon-gamma Release Tests Latent Tuberculosis - diagnosis Longitudinal Studies Male Mass Screening - methods Pediatrics Population studies Predictive Value of Tests Sensitivity and Specificity Skin tests Tuberculin Tuberculin Test Tuberculosis γ-Interferon
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Beschreibung
Zusammenfassung:	The tuberculin skin test (TST) has been preferred for screening young children for latent tuberculosis infection (LTBI) because of concerns that interferon-γ release assays (IGRAs) may be less sensitive in this high-risk population. In this study, we compared the predictive value of IGRAs to the TST for progression to tuberculosis disease in children, including those
ISSN:	0031-4005 1098-4275
DOI:	10.1542/peds.2019-1930