Serum neurofilament light as biomarker of seizure‐related neuronal injury in status epilepticus

Serum neurofilament light as biomarker of seizure‐related neuronal injury in status epilepticus

Biomarkers of neuronal damage in status epilepticus (SE) would be of great relevance for clinical and research purposes. In a retrospective cross‐sectional study, serum neurofilament light chain (NfL) levels were measured in patients with SE (30 subjects), patients with drug‐resistant epilepsy (30 s...

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Veröffentlicht in:Epilepsia (Copenhagen) 2022-01, Vol.63 (1), p.e23-e29
Hauptverfasser: Giovannini, Giada, Bedin, Roberta, Ferraro, Diana, Vaudano, Anna Elisabetta, Mandrioli, Jessica, Meletti, Stefano
Format: Artikel
Sprache:eng
Schlagworte:
Biomarkers
Brief Communication
Cerebrospinal fluid
Convulsions & seizures
Cross-Sectional Studies
Epilepsy
Humans
Intermediate Filaments
Neurofilament Proteins
neurofilaments
Patients
Retrospective Studies
Seizures
Status Epilepticus
Tau protein
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Zusammenfassung:Biomarkers of neuronal damage in status epilepticus (SE) would be of great relevance for clinical and research purposes. In a retrospective cross‐sectional study, serum neurofilament light chain (NfL) levels were measured in patients with SE (30 subjects), patients with drug‐resistant epilepsy (30 subjects), and healthy controls (30 subjects). Serum NfL levels were higher in patients with SE (median = 26.15 pg/ml) compared to both epilepsy patients (median = 7.35 pg/ml) and healthy controls (median = 6.81 pg/ml; p 
ISSN:0013-9580
1528-1167
DOI:10.1111/epi.17132