Clinical significance of the water retention and barrier function‐improving capabilities of ceramide‐containing formulations: A qualitative review
A decrease in the ceramide content of the stratum corneum is known to cause dry and barrier‐disrupted skin. In this literature review, the clinical usefulness of preparations containing natural or synthetic ceramides for water retention and barrier functions was evaluated. The PubMed, Cochrane Libra...
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Veröffentlicht in: | Journal of dermatology 2021-12, Vol.48 (12), p.1807-1816 |
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description | A decrease in the ceramide content of the stratum corneum is known to cause dry and barrier‐disrupted skin. In this literature review, the clinical usefulness of preparations containing natural or synthetic ceramides for water retention and barrier functions was evaluated. The PubMed, Cochrane Library, and Igaku Chuo Zasshi databases were searched using keywords such as “ceramide”, “skincare products”, “barrier + hydration + moisture + skin”, and “randomized trial”. All database searches were conducted in February 2019. Forty‐one reports were selected based on the following criterion: comparative control studies that evaluated the effects of ceramide‐containing formulations based on statistical evidence. Among the 41 reports, 12 were selected using the patient, intervention, comparison, and outcome approach. These 12 reports showed that external ceramide‐containing preparations can improve dry skin and barrier function in patients with atopic dermatitis. However, a double‐blinded comparative study with a large sample size is warranted for appropriate clinical use. |
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In this literature review, the clinical usefulness of preparations containing natural or synthetic ceramides for water retention and barrier functions was evaluated. The PubMed, Cochrane Library, and Igaku Chuo Zasshi databases were searched using keywords such as “ceramide”, “skincare products”, “barrier + hydration + moisture + skin”, and “randomized trial”. All database searches were conducted in February 2019. Forty‐one reports were selected based on the following criterion: comparative control studies that evaluated the effects of ceramide‐containing formulations based on statistical evidence. Among the 41 reports, 12 were selected using the patient, intervention, comparison, and outcome approach. These 12 reports showed that external ceramide‐containing preparations can improve dry skin and barrier function in patients with atopic dermatitis. However, a double‐blinded comparative study with a large sample size is warranted for appropriate clinical use.</description><subject>Atopic dermatitis</subject><subject>Ceramide</subject><subject>Ceramides</subject><subject>Clinical significance</subject><subject>Dermatitis, Atopic - drug therapy</subject><subject>dry skin</subject><subject>Eczema</subject><subject>Epidermis</subject><subject>Humans</subject><subject>Hydration</subject><subject>intercellular lipid of stratum corneum</subject><subject>Literature reviews</subject><subject>Patients</subject><subject>Review</subject><subject>Skin</subject><subject>skin barrier</subject><subject>Stratum corneum</subject><subject>Water</subject><issn>0385-2407</issn><issn>1346-8138</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2021</creationdate><recordtype>article</recordtype><sourceid>24P</sourceid><sourceid>WIN</sourceid><sourceid>EIF</sourceid><recordid>eNqFkc1u1DAUhS0EokNhzQ5ZYtPNtHYSxw4LpGoof6rEBtbWjXM9dZXYUzuZUXc8Qld9QJ4EhykjYIM3tq-_c66vDiEvOTvleZ3xsqqXipfqlNdcikdkcag8JgtWKrEsKiaPyLOUrhkrGsHZU3JUVqKpC1EtyP2qd94Z6Glya-9sPnqDNFg6XiHdwYiRRhzRjy54Cr6jLcToctVO3szFH9_v3LCJYev8mhrYQOt6NzpMs4nBCIPrMEMm-BFyr0zZEIeph1md3tBzejNBluT7FnOzrcPdc_LEQp_wxcN-TL69v_i6-ri8_PLh0-r8cmmqhotlVwslS8UKDliCFcqKouZda5jpeG1kw9pGAMq6kVKYsmo707WtUgLANraT5TF5u_fdTO2AnclzRuj1JroB4q0O4PTfL95d6XXY6qZoSl7wbHDyYBDDzYRp1INLBvsePIYp6UJIJRXPqWT09T_odZiiz-PpomaCsTpnmKmzPWViSCmiPXyGMz1nrueE9Zyw_pV5Vrz6c4YD_zvkDIg9sHM93v7PT39-d7E3_gk-5b0U</recordid><startdate>202112</startdate><enddate>202112</enddate><creator>Kono, Takeshi</creator><creator>Miyachi, Yoshiki</creator><creator>Kawashima, Makoto</creator><general>Wiley Subscription Services, Inc</general><general>John Wiley and Sons Inc</general><scope>24P</scope><scope>WIN</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>202112</creationdate><title>Clinical significance of the water retention and barrier function‐improving capabilities of ceramide‐containing formulations: A qualitative review</title><author>Kono, Takeshi ; Miyachi, Yoshiki ; Kawashima, Makoto</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c4915-d658738021ae3af58f5261dbc0cd16c790b95ae769775c34bdcdbb885aaf9fd73</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2021</creationdate><topic>Atopic dermatitis</topic><topic>Ceramide</topic><topic>Ceramides</topic><topic>Clinical significance</topic><topic>Dermatitis, Atopic - drug therapy</topic><topic>dry skin</topic><topic>Eczema</topic><topic>Epidermis</topic><topic>Humans</topic><topic>Hydration</topic><topic>intercellular lipid of stratum corneum</topic><topic>Literature reviews</topic><topic>Patients</topic><topic>Review</topic><topic>Skin</topic><topic>skin barrier</topic><topic>Stratum corneum</topic><topic>Water</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kono, Takeshi</creatorcontrib><creatorcontrib>Miyachi, Yoshiki</creatorcontrib><creatorcontrib>Kawashima, Makoto</creatorcontrib><collection>Wiley Online Library (Open Access Collection)</collection><collection>Wiley Online Library (Open Access Collection)</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Journal of dermatology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kono, Takeshi</au><au>Miyachi, Yoshiki</au><au>Kawashima, Makoto</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical significance of the water retention and barrier function‐improving capabilities of ceramide‐containing formulations: A qualitative review</atitle><jtitle>Journal of dermatology</jtitle><addtitle>J Dermatol</addtitle><date>2021-12</date><risdate>2021</risdate><volume>48</volume><issue>12</issue><spage>1807</spage><epage>1816</epage><pages>1807-1816</pages><issn>0385-2407</issn><eissn>1346-8138</eissn><abstract>A decrease in the ceramide content of the stratum corneum is known to cause dry and barrier‐disrupted skin. 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subjects | Atopic dermatitis Ceramide Ceramides Clinical significance Dermatitis, Atopic - drug therapy dry skin Eczema Epidermis Humans Hydration intercellular lipid of stratum corneum Literature reviews Patients Review Skin skin barrier Stratum corneum Water |
title | Clinical significance of the water retention and barrier function‐improving capabilities of ceramide‐containing formulations: A qualitative review |
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