Debulking different Corona (SARS-CoV-2 delta, omicron, OC43) and Influenza (H1N1, H3N2) virus strains by plant viral trap proteins in chewing gums to decrease infection and transmission

Because oral transmission of SARS-CoV-2 is 3–5 orders of magnitude higher than nasal transmission, we investigated debulking of oral viruses using viral trap proteins (CTB-ACE2, FRIL) expressed in plant cells, delivered through the chewing gum. In omicron nasopharyngeal (NP) samples, the microbubble...

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Veröffentlicht in:	Biomaterials 2022-09, Vol.288, p.121671-121671, Article 121671
Hauptverfasser:	Daniell, Henry, Nair, Smruti K., Guan, Hancheng, Guo, Yuwei, Kulchar, Rachel J., Torres, Marcelo D.T., Shahed-Al-Mahmud, Md, Wakade, Geetanjali, Liu, Yo-Min, Marques, Andrew D., Graham-Wooten, Jevon, Zhou, Wan, Wang, Ping, Molugu, Sudheer K., de Araujo, William R., de la Fuente-Nunez, Cesar, Ma, Che, Short, William R., Tebas, Pablo, Margulies, Kenneth B., Bushman, Frederic D., Mante, Francis K., Ricciardi, Robert P., Collman, Ronald G., Wolff, Mark S.
Format:	Artikel
Sprache:	eng
Schlagworte:	Angiotensin-Converting Enzyme 2 Betacoronavirus 1 biocompatible materials Chewing Gum clinical trials COVID-19 Cytoreduction Surgical Procedures dose response Humans influenza Influenza A Virus, H1N1 Subtype Influenza A Virus, H3N2 Subtype Influenza, Human Lablab purpureus microbubbles nose Plant Proteins Powders saliva SARS-CoV-2 Severe acute respiratory syndrome coronavirus 2 viral load Viral Proteins viruses
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Zusammenfassung:	Because oral transmission of SARS-CoV-2 is 3–5 orders of magnitude higher than nasal transmission, we investigated debulking of oral viruses using viral trap proteins (CTB-ACE2, FRIL) expressed in plant cells, delivered through the chewing gum. In omicron nasopharyngeal (NP) samples, the microbubble count (based on N-antigen) was significantly reduced by 20 μg of FRIL (p
ISSN:	0142-9612 1878-5905 1878-5905
DOI:	10.1016/j.biomaterials.2022.121671