Thiazolidinediones (TZDs) enhance insulin secretory response via GPR40 and adenylate cyclase (AC)

Thiazolidinediones are synthetic PPARγ ligands that enhance insulin sensitivity, and that could increase insulin secretion from β‐cells. However, the functional role and mechanism(s) of action in pancreatic β‐cells have not been investigated in detail. These results suggest that TZDs could increase...

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Veröffentlicht in:	Journal of cellular physiology 2021-12, Vol.236 (12), p.8137-8147
Hauptverfasser:	Hwang, Mina, Kim, Hyo‐Sup, Jin, Sang‐Man, Hur, Kyu Yeon, Kim, Jae‐Hyeon, Lee, Moon‐Kyu
Format:	Artikel
Sprache:	eng
Schlagworte:	Adenylate cyclase adenylyl cyclase Adenylyl Cyclases - drug effects Animals cAMP glucolipotoxicity GPR40 Humans Hypoglycemic Agents - metabolism Hypoglycemic Agents - pharmacology Insulin Insulin - metabolism Insulin secretion Insulin Secretion - drug effects Insulin-Secreting Cells - drug effects Insulin-Secreting Cells - metabolism Ligands lobeglitazone Peroxisome proliferator-activated receptors Receptors, G-Protein-Coupled - drug effects Sensitivity enhancement Thiazolidinediones Thiazolidinediones - pharmacology
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Zusammenfassung:	Thiazolidinediones are synthetic PPARγ ligands that enhance insulin sensitivity, and that could increase insulin secretion from β‐cells. However, the functional role and mechanism(s) of action in pancreatic β‐cells have not been investigated in detail. These results suggest that TZDs could increase GPR40 and adenylyl cyclase expressions in pancreatic β‐cells in a PPARγ‐dependent manner, which were associated with increased incretin sensitivity and protection against lipotoxicity
ISSN:	0021-9541 1097-4652
DOI:	10.1002/jcp.30467