A ring expansion approach to N-oxy-2,5-diketopiperazines

A ring expansion approach to N-oxy-2,5-diketopiperazines

[Display omitted] A ring expansion of tetramic acids (pyrrolidine-2,4-diones) to N-oxy-2,5-diketopiperazines (DKPs) is described. This method allows for the facile and late-stage construction of the hydroxamic acid moiety and can thereby serve as a general method for accessing N-oxy-2,5-DKP natural...

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Veröffentlicht in:Tetrahedron letters 2022-06, Vol.99, p.153851, Article 153851
Hauptverfasser: Jackson, Amy C., Olsen, James T., Sundstrom, Sasha, Lambert, Kyle M., Wood, John L.
Format: Artikel
Sprache:eng
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Zusammenfassung:[Display omitted] A ring expansion of tetramic acids (pyrrolidine-2,4-diones) to N-oxy-2,5-diketopiperazines (DKPs) is described. This method allows for the facile and late-stage construction of the hydroxamic acid moiety and can thereby serve as a general method for accessing N-oxy-2,5-DKP natural products.
ISSN:0040-4039
1873-3581
DOI:10.1016/j.tetlet.2022.153851