The Appropriate of Cone Depth in Loop Electrical Excision Procedure (LEEP) for Negative Pathological Margin from High Grade Precancerous Lesion of Cervix, Retrospective Study
To determine the appropriate cone depth for treating high grade precancerous lesions to achieve negative pathological margins of cones from LEEPs. Other factors associated with positive pathological margin were also investigated. A Retrospective study recruited 170 patients who received indications...
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| Veröffentlicht in: | Asian Pacific Journal of Cancer Prevention 2022-02, Vol.23 (2), p.659-664 |
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| creator | Srijarusith, Noppames Rodpenpear, Nopporn |
| description | To determine the appropriate cone depth for treating high grade precancerous lesions to achieve negative pathological margins of cones from LEEPs. Other factors associated with positive pathological margin were also investigated.
A Retrospective study recruited 170 patients who received indications for LEEP during January 2015 to July 2020 were enrolled. The participants were operated by a single cut of LEEP and not had previously conization before. All patient data were collected into two groups, including negative and positive cone margin groups. Then, we used the cone depth by calculating from cone tissue after formalin fixation to eliminate shrinkage effect. The appropriate cut-off points for cone depth were calculated by ROC and analyzed factors that influence positive cone margin.
The depth of cone (mm ±SD) of negative margin group was 8.70 (±3.36) and 6.13 (±2.28) mm in positive margin group. The appropriate cut-off points for cone depth were calculated by ROC presented at resection depth of 7.21 mm, which displayed proper cone depth with a sensitivity of 63.53% and specificity of 71.76%. Elderly age (adjusted OR 1.061, 95%CI 1.008-1.117, p=0.002), number of quadrants of lesion involvement (adjusted OR 1.182, 95%CI 1.312-2.513, p= |
| doi_str_mv | 10.31557/APJCP.2022.23.2.659 |
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A Retrospective study recruited 170 patients who received indications for LEEP during January 2015 to July 2020 were enrolled. The participants were operated by a single cut of LEEP and not had previously conization before. All patient data were collected into two groups, including negative and positive cone margin groups. Then, we used the cone depth by calculating from cone tissue after formalin fixation to eliminate shrinkage effect. The appropriate cut-off points for cone depth were calculated by ROC and analyzed factors that influence positive cone margin.
The depth of cone (mm ±SD) of negative margin group was 8.70 (±3.36) and 6.13 (±2.28) mm in positive margin group. The appropriate cut-off points for cone depth were calculated by ROC presented at resection depth of 7.21 mm, which displayed proper cone depth with a sensitivity of 63.53% and specificity of 71.76%. Elderly age (adjusted OR 1.061, 95%CI 1.008-1.117, p=0.002), number of quadrants of lesion involvement (adjusted OR 1.182, 95%CI 1.312-2.513, p=<0.001) and glandular involvement (adjusted OR 3.648, 95%CI 1.605-8.292, p=0.002) were the significant risk factors for positive margin.
The appropriate cone depth for treating high grade precancerous lesions was at least 7.21 mm to achieve a negative cone margin from LEEP. The significant factors associated with positive cone margin include elderly age, more quadrants of lesion involvement and glandular involvement.</description><identifier>ISSN: 2476-762X</identifier><identifier>ISSN: 1513-7368</identifier><identifier>EISSN: 2476-762X</identifier><identifier>DOI: 10.31557/APJCP.2022.23.2.659</identifier><identifier>PMID: 35225479</identifier><language>eng</language><publisher>Thailand: West Asia Organization for Cancer Prevention</publisher><subject>Adult ; Cervix Uteri - pathology ; Cervix Uteri - surgery ; Conization - methods ; Electrosurgery - methods ; Female ; Humans ; Margins of Excision ; Middle Aged ; Neoplasm, Residual ; Precancerous Conditions - pathology ; Precancerous Conditions - surgery ; Reference Values ; Retrospective Studies ; ROC Curve ; Treatment Outcome ; Uterine Cervical Neoplasms - pathology ; Uterine Cervical Neoplasms - surgery</subject><ispartof>Asian Pacific Journal of Cancer Prevention, 2022-02, Vol.23 (2), p.659-664</ispartof><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><orcidid>0000000296912797 ; 0000-0002-8642-209X</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272615/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9272615/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,723,776,780,860,881,27901,27902,53766,53768</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35225479$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Srijarusith, Noppames</creatorcontrib><creatorcontrib>Rodpenpear, Nopporn</creatorcontrib><title>The Appropriate of Cone Depth in Loop Electrical Excision Procedure (LEEP) for Negative Pathological Margin from High Grade Precancerous Lesion of Cervix, Retrospective Study</title><title>Asian Pacific Journal of Cancer Prevention</title><addtitle>Asian Pac J Cancer Prev</addtitle><description>To determine the appropriate cone depth for treating high grade precancerous lesions to achieve negative pathological margins of cones from LEEPs. Other factors associated with positive pathological margin were also investigated.
A Retrospective study recruited 170 patients who received indications for LEEP during January 2015 to July 2020 were enrolled. The participants were operated by a single cut of LEEP and not had previously conization before. All patient data were collected into two groups, including negative and positive cone margin groups. Then, we used the cone depth by calculating from cone tissue after formalin fixation to eliminate shrinkage effect. The appropriate cut-off points for cone depth were calculated by ROC and analyzed factors that influence positive cone margin.
The depth of cone (mm ±SD) of negative margin group was 8.70 (±3.36) and 6.13 (±2.28) mm in positive margin group. The appropriate cut-off points for cone depth were calculated by ROC presented at resection depth of 7.21 mm, which displayed proper cone depth with a sensitivity of 63.53% and specificity of 71.76%. Elderly age (adjusted OR 1.061, 95%CI 1.008-1.117, p=0.002), number of quadrants of lesion involvement (adjusted OR 1.182, 95%CI 1.312-2.513, p=<0.001) and glandular involvement (adjusted OR 3.648, 95%CI 1.605-8.292, p=0.002) were the significant risk factors for positive margin.
The appropriate cone depth for treating high grade precancerous lesions was at least 7.21 mm to achieve a negative cone margin from LEEP. The significant factors associated with positive cone margin include elderly age, more quadrants of lesion involvement and glandular involvement.</description><subject>Adult</subject><subject>Cervix Uteri - pathology</subject><subject>Cervix Uteri - surgery</subject><subject>Conization - methods</subject><subject>Electrosurgery - methods</subject><subject>Female</subject><subject>Humans</subject><subject>Margins of Excision</subject><subject>Middle Aged</subject><subject>Neoplasm, Residual</subject><subject>Precancerous Conditions - pathology</subject><subject>Precancerous Conditions - surgery</subject><subject>Reference Values</subject><subject>Retrospective Studies</subject><subject>ROC Curve</subject><subject>Treatment Outcome</subject><subject>Uterine Cervical Neoplasms - pathology</subject><subject>Uterine Cervical Neoplasms - surgery</subject><issn>2476-762X</issn><issn>1513-7368</issn><issn>2476-762X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNpVkdFu0zAUhi0EYmPwBgj5kkk0i-3YTm6QqhI2pmxE25C4s1z7JDFK48hJq-2leEbcDqZx5SP5_N8v-0PoPUkTRjiXZ8v6clUnNKU0oSyhieDFC3RMMykWUtCfL5_NR-jNNP1K04znkr9GR4xTyjNZHKPfdx3g5TgGPwanZ8C-wSs_AP4C49xhN-DK-xGXPZg5OKN7XN4bNzk_4Dp4A3YbAH-syrI-xY0P-BpaPbsd4FrPne99e8hc6dBGVBP8Bl-4tsPnQdu4E8DowUDw2wlXcKDu-yHs3P0nfANz8NMYm_fA23lrH96iV43uJ3j39zxBP76Wd6uLRfX9_NtqWS0MlbRYEGp0IXJpDRUFEUQUGQUri9RkRgBY1hgh8jUDzVNOWJZbkq8NZJSvJSdWsxP0-ZE7btcbsAaGOehexT_a6PCgvHbq_5vBdar1O1XEfkF4BGSPABOfMAVonrIkVQd_6uBP7f0pyhRV0V-MfXje-xT6J4z9Aat8mrE</recordid><startdate>20220201</startdate><enddate>20220201</enddate><creator>Srijarusith, Noppames</creator><creator>Rodpenpear, Nopporn</creator><general>West Asia Organization for Cancer Prevention</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>5PM</scope><orcidid>https://orcid.org/0000000296912797</orcidid><orcidid>https://orcid.org/0000-0002-8642-209X</orcidid></search><sort><creationdate>20220201</creationdate><title>The Appropriate of Cone Depth in Loop Electrical Excision Procedure (LEEP) for Negative Pathological Margin from High Grade Precancerous Lesion of Cervix, Retrospective Study</title><author>Srijarusith, Noppames ; Rodpenpear, Nopporn</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c2729-12ca9687dc2691616942ed790c4c6eed3fc668b3ea5051348d18bce425b751da3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Adult</topic><topic>Cervix Uteri - pathology</topic><topic>Cervix Uteri - surgery</topic><topic>Conization - methods</topic><topic>Electrosurgery - methods</topic><topic>Female</topic><topic>Humans</topic><topic>Margins of Excision</topic><topic>Middle Aged</topic><topic>Neoplasm, Residual</topic><topic>Precancerous Conditions - pathology</topic><topic>Precancerous Conditions - surgery</topic><topic>Reference Values</topic><topic>Retrospective Studies</topic><topic>ROC Curve</topic><topic>Treatment Outcome</topic><topic>Uterine Cervical Neoplasms - pathology</topic><topic>Uterine Cervical Neoplasms - surgery</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Srijarusith, Noppames</creatorcontrib><creatorcontrib>Rodpenpear, Nopporn</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Srijarusith, Noppames</au><au>Rodpenpear, Nopporn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The Appropriate of Cone Depth in Loop Electrical Excision Procedure (LEEP) for Negative Pathological Margin from High Grade Precancerous Lesion of Cervix, Retrospective Study</atitle><jtitle>Asian Pacific Journal of Cancer Prevention</jtitle><addtitle>Asian Pac J Cancer Prev</addtitle><date>2022-02-01</date><risdate>2022</risdate><volume>23</volume><issue>2</issue><spage>659</spage><epage>664</epage><pages>659-664</pages><issn>2476-762X</issn><issn>1513-7368</issn><eissn>2476-762X</eissn><abstract>To determine the appropriate cone depth for treating high grade precancerous lesions to achieve negative pathological margins of cones from LEEPs. Other factors associated with positive pathological margin were also investigated.
A Retrospective study recruited 170 patients who received indications for LEEP during January 2015 to July 2020 were enrolled. The participants were operated by a single cut of LEEP and not had previously conization before. All patient data were collected into two groups, including negative and positive cone margin groups. Then, we used the cone depth by calculating from cone tissue after formalin fixation to eliminate shrinkage effect. The appropriate cut-off points for cone depth were calculated by ROC and analyzed factors that influence positive cone margin.
The depth of cone (mm ±SD) of negative margin group was 8.70 (±3.36) and 6.13 (±2.28) mm in positive margin group. The appropriate cut-off points for cone depth were calculated by ROC presented at resection depth of 7.21 mm, which displayed proper cone depth with a sensitivity of 63.53% and specificity of 71.76%. Elderly age (adjusted OR 1.061, 95%CI 1.008-1.117, p=0.002), number of quadrants of lesion involvement (adjusted OR 1.182, 95%CI 1.312-2.513, p=<0.001) and glandular involvement (adjusted OR 3.648, 95%CI 1.605-8.292, p=0.002) were the significant risk factors for positive margin.
The appropriate cone depth for treating high grade precancerous lesions was at least 7.21 mm to achieve a negative cone margin from LEEP. The significant factors associated with positive cone margin include elderly age, more quadrants of lesion involvement and glandular involvement.</abstract><cop>Thailand</cop><pub>West Asia Organization for Cancer Prevention</pub><pmid>35225479</pmid><doi>10.31557/APJCP.2022.23.2.659</doi><tpages>6</tpages><orcidid>https://orcid.org/0000000296912797</orcidid><orcidid>https://orcid.org/0000-0002-8642-209X</orcidid><oa>free_for_read</oa></addata></record> |
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| source | MEDLINE; DOAJ Directory of Open Access Journals; Elektronische Zeitschriftenbibliothek - Frei zugängliche E-Journals; PubMed Central; Free E- Journals |
| subjects | Adult Cervix Uteri - pathology Cervix Uteri - surgery Conization - methods Electrosurgery - methods Female Humans Margins of Excision Middle Aged Neoplasm, Residual Precancerous Conditions - pathology Precancerous Conditions - surgery Reference Values Retrospective Studies ROC Curve Treatment Outcome Uterine Cervical Neoplasms - pathology Uterine Cervical Neoplasms - surgery |
| title | The Appropriate of Cone Depth in Loop Electrical Excision Procedure (LEEP) for Negative Pathological Margin from High Grade Precancerous Lesion of Cervix, Retrospective Study |
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