Investigation of the Molecular Mechanisms Underlying the Antiatherogenic Actions of Kaempferol in Human THP-1 Macrophages

Cardiovascular disease (CVD) is causing high mortality worldwide (World Health Organization-WHO, 2015). Atherosclerosis, the hardening and narrowing of arteries caused by the accumulation of fatty acids and lipids (cholesterol plaques), is a main reason of stroke, myocardial infarction, and angina....

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Veröffentlicht in:	International journal of molecular sciences 2022-07, Vol.23 (13), p.7461
Hauptverfasser:	Huwait, Etimad, Ayoub, Maha, Karim, Sajjad
Format:	Artikel
Sprache:	eng
Schlagworte:	Angina Apolipoproteins Arteries Arteriosclerosis Atherosclerosis Atherosclerosis - drug therapy Atherosclerosis - metabolism Boyden chamber Cardiovascular diseases Cardiovascular Diseases - metabolism Cell adhesion Cell growth Cell lines Cerebral infarction Chemokine CCL2 - genetics Chemokine CCL2 - metabolism Cholesterol Cholesterol - metabolism Cytokines Cytotoxicity Enzymes Gene expression Genotype & phenotype Humans Inflammation Intercellular adhesion molecule 1 Interferon Interferon-gamma - metabolism Kaempferol Kinases Lipids Macrophages Macrophages - metabolism Metabolism Molecular modelling Monocyte chemoattractant protein 1 Monocytes Monocytes - metabolism Myocardial infarction Plaques Statins γ-Interferon
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Zusammenfassung:	Cardiovascular disease (CVD) is causing high mortality worldwide (World Health Organization-WHO, 2015). Atherosclerosis, the hardening and narrowing of arteries caused by the accumulation of fatty acids and lipids (cholesterol plaques), is a main reason of stroke, myocardial infarction, and angina. Present therapies for cardiovascular disease basically use statins such as β-Hydroxy β-methylglutaryl-CoA, with
ISSN:	1422-0067 1661-6596 1422-0067
DOI:	10.3390/ijms23137461