Neutralization of the SARS-CoV-2 Omicron BA.4/5 and BA.2.12.1 Subvariants

After two doses of mRNA vaccine, health care workers had less viral neutralizing-antibody activity against the BA.4/5 and BA.2.12.1 omicron subvariants than against the BA.1 and BA.2 subvariants, but titers increased significantly with a booster dose.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	The New England journal of medicine 2022-06, Vol.386 (26), p.2526-2528
Hauptverfasser:	Qu, Panke, Faraone, Julia, Evans, John P., Zou, Xue, Zheng, Yi-Min, Carlin, Claire, Bednash, Joseph S., Lozanski, Gerard, Mallampalli, Rama K., Saif, Linda J., Oltz, Eugene M., Mohler, Peter J., Gumina, Richard J., Liu, Shan-Lu
Format:	Artikel
Sprache:	eng
Schlagworte:	Antibodies Antibodies, Neutralizing Coronavirus Coronaviruses Correspondence COVID-19 COVID-19 - diagnosis COVID-19 - immunology COVID-19 - virology COVID-19 vaccines Health care Hospitalization Humans Infectious Disease Intensive care Medical personnel mRNA Mutation Neutralization Tests Pandemics SARS-CoV-2 - immunology Severe acute respiratory syndrome coronavirus 2 Spike Glycoprotein, Coronavirus - immunology Vaccination Vaccines Viral Infections
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	After two doses of mRNA vaccine, health care workers had less viral neutralizing-antibody activity against the BA.4/5 and BA.2.12.1 omicron subvariants than against the BA.1 and BA.2 subvariants, but titers increased significantly with a booster dose.
ISSN:	0028-4793 1533-4406
DOI:	10.1056/NEJMc2206725