Vorinostat and isotretinoin with chemotherapy in young children with embryonal brain tumors: A report from the Pediatric Brain Tumor Consortium (PBTC-026)

Abstract Background Embryonal tumors of the CNS are the most common malignant tumors occurring in the first years of life. This study evaluated the feasibility and safety of incorporating novel non-cytotoxic therapy with vorinostat and isotretinoin to an intensive cytotoxic chemotherapy backbone. Me...

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Veröffentlicht in:	Neuro-oncology (Charlottesville, Va.) Va.), 2022-07, Vol.24 (7), p.1178-1190
Hauptverfasser:	Leary, Sarah E S, Kilburn, Lindsay, Geyer, J Russell, Kocak, Mehmet, Huang, Jie, Smith, Kyle S, Hadley, Jennifer, Ermoian, Ralph, MacDonald, Tobey J, Goldman, Stewart, Phillips, Peter, Young Poussaint, Tina, Olson, James M, Ellison, David W, Dunkel, Ira J, Fouladi, Maryam, Onar-Thomas, Arzu, Northcott, Paul A
Format:	Artikel
Sprache:	eng
Schlagworte:	Antineoplastic Combined Chemotherapy Protocols - therapeutic use Brain Neoplasms - pathology Cerebellar Neoplasms - drug therapy Child Child, Preschool Cyclophosphamide Etoposide Female Humans Infant Isotretinoin - therapeutic use Male Medulloblastoma - pathology Neoplasms, Germ Cell and Embryonal - drug therapy Neuroectodermal Tumors, Primitive - drug therapy Pediatric Neuro-Oncology Prospective Studies Vincristine Vorinostat
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Zusammenfassung:	Abstract Background Embryonal tumors of the CNS are the most common malignant tumors occurring in the first years of life. This study evaluated the feasibility and safety of incorporating novel non-cytotoxic therapy with vorinostat and isotretinoin to an intensive cytotoxic chemotherapy backbone. Methods PBTC-026 was a prospective multi-institutional clinical trial for children
ISSN:	1522-8517 1523-5866
DOI:	10.1093/neuonc/noab293