Ribosome collisions: New ways to initiate ribosome rescue

Ribosome collisions: New ways to initiate ribosome rescue

When ribosomes collide while translating the same mRNA, a MutS-like protein can pry apart the leading ribosome and a nuclease can cut the mRNA between the collided ribosomes to initiate ribosome rescue and recycling. When ribosomes collide while translating the same mRNA, a MutS-like protein can pry...

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Veröffentlicht in:Current biology 2022-05, Vol.32 (10), p.R469-R472
Hauptverfasser: Leedom, Stephanie L., Keiler, Kenneth C.
Format: Artikel
Sprache:eng
Schlagworte:
Humans
Protein Biosynthesis
Proteins - metabolism
Ribosomes - genetics
Ribosomes - metabolism
RNA, Messenger - genetics
RNA, Messenger - metabolism
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Zusammenfassung:When ribosomes collide while translating the same mRNA, a MutS-like protein can pry apart the leading ribosome and a nuclease can cut the mRNA between the collided ribosomes to initiate ribosome rescue and recycling. When ribosomes collide while translating the same mRNA, a MutS-like protein can pry apart the leading ribosome and a nuclease can cut the mRNA between the collided ribosomes to initiate ribosome rescue and recycling.
ISSN:0960-9822
1879-0445
DOI:10.1016/j.cub.2022.04.038