Bilateral massive nephromegaly as a presenting manifestation of mixed phenotype acute leukaemia

On flow cytometry, these blasts were positive for CD19 and CD20 (marker of B lymphocyte), CD5 and CD13 (myeloid lineage marker), CD33 (myeloid marker), CD34 (marker of blast) and myeloperoxidase (MPO myeloid marker) (figure 2C,D); suggestive of Mixed Phenotype Acute Leukaemia (MPAL-mixed myeloid/B cell) with renal infiltration. Mixed phenotype acute leukemia: a study of 61 cases using World Health organization and European group for the immunological classification of leukaemias criteria. Radiographics 2016; 36: 1038–54. doi:10.1148/rg.2016150213 http://www.ncbi.nlm.nih.gov/pubmed/27257766 4 Cernan M, Szotkowski T, Pikalova Z. Mixed-phenotype acute leukemia: state-of-the-art of the diagnosis, classification and treatment.