Serum IgG4 cut-off of 70 mg/dL is associated with a shorter time to cirrhosis decompensation and liver transplantation in primary sclerosing cholangitis patients

Serum IgG4 cut-off of 70 mg/dL is associated with a shorter time to cirrhosis decompensation and liver transplantation in primary sclerosing cholangitis patients

BACKGROUND: Primary sclerosing cholangitis (PSC) is an immune-mediated biliary disorder of unknown etiology with no effective treatment. The purpose of this study was to better prognosticate the development of cirrhosis, decompensation, and requirement for liver transplantation (LT) in PSC patients...

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Veröffentlicht in:Canadian liver journal 2022-02, Vol.5 (1), p.31-42
Hauptverfasser: Peerani, Farhad, Du, Lillian, Lytvyak, Ellina, Bain, Vincent G, Mason, Andrew L, Bailey, Robert J, Montano-Loza, Aldo J
Format: Artikel
Sprache:eng
Schlagworte:
Development and progression
Gastrointestinal diseases
Immunoglobulin G
Liver cirrhosis
Original Research
Transplantation of organs, tissues, etc
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Zusammenfassung:BACKGROUND: Primary sclerosing cholangitis (PSC) is an immune-mediated biliary disorder of unknown etiology with no effective treatment. The purpose of this study was to better prognosticate the development of cirrhosis, decompensation, and requirement for liver transplantation (LT) in PSC patients based on serum immunoglobulin G4 (IgG4) levels. METHODS: A retrospective chart review was conducted on PSC patients seen at the University of Alberta Hospital between 2002 and 2017. PSC patients were categorized as high IgG4 group (≥70 mg/dL) or normal IgG4 group (
ISSN:2561-4444
2561-4444
DOI:10.3138/canlivj-2021-0023