Preparation and Release of pH-Sensitive β-Cyclodextrin Derivative Micelles Loaded with Paclitaxel
In this paper, a new amphiphilic mono-6-β-cyclodextrin octadecylimine (6-β-CD-N-ODMA) copolymer was synthesized based on β-cyclodextrin and octadecylamine, which can self-assemble to form polymeric micelles. Drug-loaded micelles (a new drug carrier) were obtained using 6-β-CD-N-ODMA and paclitaxel (...
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| Veröffentlicht in: | Polymers 2022-06, Vol.14 (12), p.2482 |
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| creator | Zhao, Meirong Jiang, Weiwei Xie, Xinrong Jaiswal, Yogini Williams, Leonard Wei, Mei Mo, Ying Guan, Yifu Yang, Hua |
| description | In this paper, a new amphiphilic mono-6-β-cyclodextrin octadecylimine (6-β-CD-N-ODMA) copolymer was synthesized based on β-cyclodextrin and octadecylamine, which can self-assemble to form polymeric micelles. Drug-loaded micelles (a new drug carrier) were obtained using 6-β-CD-N-ODMA and paclitaxel (PTX) by the dialysis method. Orthogonal experiments were used to optimize the preparation method of the drug-loaded micelles. The drug-loading content of the carrier prepared by the optimized method was 1.97%. The physicochemical properties of blank micelles and drug-loaded micelles were evaluated by the fluorescence probe method, infrared spectra, dynamic light scattering, and scanning electron microscopy. The release properties of the carrier were investigated. The carrier has good pH sensitivity and the cumulative release rate after 96 h was 88% in PBS (pH = 5.0). The Ritger–Peppas equation is the optimal model for PTX released at pH 5.0, implying that the hydrolysis effect of 6-β-CD-N-ODMA is the main reason for PTX release. The results indicate that the developed carrier can increase the solubility of PTX and possess potential for increased clinical efficacy of PTX. |
| doi_str_mv | 10.3390/polym14122482 |
| format | Article |
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Drug-loaded micelles (a new drug carrier) were obtained using 6-β-CD-N-ODMA and paclitaxel (PTX) by the dialysis method. Orthogonal experiments were used to optimize the preparation method of the drug-loaded micelles. The drug-loading content of the carrier prepared by the optimized method was 1.97%. The physicochemical properties of blank micelles and drug-loaded micelles were evaluated by the fluorescence probe method, infrared spectra, dynamic light scattering, and scanning electron microscopy. The release properties of the carrier were investigated. The carrier has good pH sensitivity and the cumulative release rate after 96 h was 88% in PBS (pH = 5.0). The Ritger–Peppas equation is the optimal model for PTX released at pH 5.0, implying that the hydrolysis effect of 6-β-CD-N-ODMA is the main reason for PTX release. The results indicate that the developed carrier can increase the solubility of PTX and possess potential for increased clinical efficacy of PTX.</description><identifier>ISSN: 2073-4360</identifier><identifier>EISSN: 2073-4360</identifier><identifier>DOI: 10.3390/polym14122482</identifier><identifier>PMID: 35746058</identifier><language>eng</language><publisher>Basel: MDPI AG</publisher><subject>Cancer therapies ; Copolymers ; Cyclodextrins ; Dosage and administration ; Drug carriers ; Drug delivery systems ; Drugs ; Efficiency ; Fluorescent indicators ; Hemodialysis ; Infrared spectra ; Methods ; Micelles ; Optimization ; Paclitaxel ; Photon correlation spectroscopy ; Vehicles</subject><ispartof>Polymers, 2022-06, Vol.14 (12), p.2482</ispartof><rights>COPYRIGHT 2022 MDPI AG</rights><rights>2022 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><rights>2022 by the authors. 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c459t-4a50107c06ca932e5fb47373212922ab5c0f736eff592ede74f00ee3a157a9423</citedby><cites>FETCH-LOGICAL-c459t-4a50107c06ca932e5fb47373212922ab5c0f736eff592ede74f00ee3a157a9423</cites><orcidid>0000-0003-0886-5204</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227914/pdf/$$EPDF$$P50$$Gpubmedcentral$$Hfree_for_read</linktopdf><linktohtml>$$Uhttps://www.ncbi.nlm.nih.gov/pmc/articles/PMC9227914/$$EHTML$$P50$$Gpubmedcentral$$Hfree_for_read</linktohtml><link.rule.ids>230,314,727,780,784,885,27924,27925,53791,53793</link.rule.ids></links><search><creatorcontrib>Zhao, Meirong</creatorcontrib><creatorcontrib>Jiang, Weiwei</creatorcontrib><creatorcontrib>Xie, Xinrong</creatorcontrib><creatorcontrib>Jaiswal, Yogini</creatorcontrib><creatorcontrib>Williams, Leonard</creatorcontrib><creatorcontrib>Wei, Mei</creatorcontrib><creatorcontrib>Mo, Ying</creatorcontrib><creatorcontrib>Guan, Yifu</creatorcontrib><creatorcontrib>Yang, Hua</creatorcontrib><title>Preparation and Release of pH-Sensitive β-Cyclodextrin Derivative Micelles Loaded with Paclitaxel</title><title>Polymers</title><description>In this paper, a new amphiphilic mono-6-β-cyclodextrin octadecylimine (6-β-CD-N-ODMA) copolymer was synthesized based on β-cyclodextrin and octadecylamine, which can self-assemble to form polymeric micelles. Drug-loaded micelles (a new drug carrier) were obtained using 6-β-CD-N-ODMA and paclitaxel (PTX) by the dialysis method. Orthogonal experiments were used to optimize the preparation method of the drug-loaded micelles. The drug-loading content of the carrier prepared by the optimized method was 1.97%. The physicochemical properties of blank micelles and drug-loaded micelles were evaluated by the fluorescence probe method, infrared spectra, dynamic light scattering, and scanning electron microscopy. The release properties of the carrier were investigated. The carrier has good pH sensitivity and the cumulative release rate after 96 h was 88% in PBS (pH = 5.0). The Ritger–Peppas equation is the optimal model for PTX released at pH 5.0, implying that the hydrolysis effect of 6-β-CD-N-ODMA is the main reason for PTX release. The results indicate that the developed carrier can increase the solubility of PTX and possess potential for increased clinical efficacy of PTX.</description><subject>Cancer therapies</subject><subject>Copolymers</subject><subject>Cyclodextrins</subject><subject>Dosage and administration</subject><subject>Drug carriers</subject><subject>Drug delivery systems</subject><subject>Drugs</subject><subject>Efficiency</subject><subject>Fluorescent indicators</subject><subject>Hemodialysis</subject><subject>Infrared spectra</subject><subject>Methods</subject><subject>Micelles</subject><subject>Optimization</subject><subject>Paclitaxel</subject><subject>Photon correlation spectroscopy</subject><subject>Vehicles</subject><issn>2073-4360</issn><issn>2073-4360</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>ABUWG</sourceid><sourceid>AFKRA</sourceid><sourceid>AZQEC</sourceid><sourceid>BENPR</sourceid><sourceid>CCPQU</sourceid><sourceid>DWQXO</sourceid><recordid>eNptkstuFDEQRVsIRKKQJXtLbNh08LM9vUGKhkeQBhHxWFs17nLiyG03ds-Q-S0-hG_CQyKUQdgLl6pO3dKVq2meM3omRE9fTSnsRiYZ53LBHzXHnGrRStHRxw_io-a0lBtaj1Rdx_TT5kgoLTuqFsfN-jLjBBlmnyKBOJDPGBAKkuTIdNF-wVj87LdIfv1slzsb0oC3c_aRvMHst_Cn9NFbDAELWSUYcCA__HxNLsEGP8MthmfNEweh4On9e9J8e_f26_KiXX16_2F5vmqtVP3cSlCUUW1pZ6EXHJVbSy204Iz3nMNaWeq06NA51XMcUEtHKaIApjT0kouT5vWd7rRZjzhYjHOGYKbsR8g7k8Cbw0r01-YqbU2V1z2TVeDlvUBO3zdYZjP6srcGEdOmGN4tGBWa0q6iL_5Bb9Imx2qvUrpfCMofUlcQ0PjoUp1r96LmXHPO9h-iKnX2H6reAUdvU0Tna_6gob1rsDmVktH99cio2e-FOdgL8RuWkqm9</recordid><startdate>20220618</startdate><enddate>20220618</enddate><creator>Zhao, Meirong</creator><creator>Jiang, Weiwei</creator><creator>Xie, Xinrong</creator><creator>Jaiswal, Yogini</creator><creator>Williams, Leonard</creator><creator>Wei, Mei</creator><creator>Mo, Ying</creator><creator>Guan, Yifu</creator><creator>Yang, Hua</creator><general>MDPI AG</general><general>MDPI</general><scope>AAYXX</scope><scope>CITATION</scope><scope>7SR</scope><scope>8FD</scope><scope>8FE</scope><scope>8FG</scope><scope>ABJCF</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BENPR</scope><scope>BGLVJ</scope><scope>CCPQU</scope><scope>D1I</scope><scope>DWQXO</scope><scope>HCIFZ</scope><scope>JG9</scope><scope>KB.</scope><scope>PDBOC</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>5PM</scope><orcidid>https://orcid.org/0000-0003-0886-5204</orcidid></search><sort><creationdate>20220618</creationdate><title>Preparation and Release of pH-Sensitive β-Cyclodextrin Derivative Micelles Loaded with Paclitaxel</title><author>Zhao, Meirong ; Jiang, Weiwei ; Xie, Xinrong ; Jaiswal, Yogini ; Williams, Leonard ; Wei, Mei ; Mo, Ying ; Guan, Yifu ; Yang, Hua</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c459t-4a50107c06ca932e5fb47373212922ab5c0f736eff592ede74f00ee3a157a9423</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Cancer therapies</topic><topic>Copolymers</topic><topic>Cyclodextrins</topic><topic>Dosage and administration</topic><topic>Drug carriers</topic><topic>Drug delivery systems</topic><topic>Drugs</topic><topic>Efficiency</topic><topic>Fluorescent indicators</topic><topic>Hemodialysis</topic><topic>Infrared spectra</topic><topic>Methods</topic><topic>Micelles</topic><topic>Optimization</topic><topic>Paclitaxel</topic><topic>Photon correlation spectroscopy</topic><topic>Vehicles</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Zhao, Meirong</creatorcontrib><creatorcontrib>Jiang, Weiwei</creatorcontrib><creatorcontrib>Xie, Xinrong</creatorcontrib><creatorcontrib>Jaiswal, Yogini</creatorcontrib><creatorcontrib>Williams, Leonard</creatorcontrib><creatorcontrib>Wei, Mei</creatorcontrib><creatorcontrib>Mo, Ying</creatorcontrib><creatorcontrib>Guan, Yifu</creatorcontrib><creatorcontrib>Yang, Hua</creatorcontrib><collection>CrossRef</collection><collection>Engineered Materials Abstracts</collection><collection>Technology Research Database</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Technology Collection</collection><collection>Materials Science & Engineering Collection</collection><collection>ProQuest Central (Alumni Edition)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central Essentials</collection><collection>ProQuest Central</collection><collection>Technology Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Materials Science Collection</collection><collection>ProQuest Central Korea</collection><collection>SciTech Premium Collection</collection><collection>Materials Research Database</collection><collection>Materials Science Database</collection><collection>Materials Science Collection</collection><collection>Access via ProQuest (Open Access)</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Polymers</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Zhao, Meirong</au><au>Jiang, Weiwei</au><au>Xie, Xinrong</au><au>Jaiswal, Yogini</au><au>Williams, Leonard</au><au>Wei, Mei</au><au>Mo, Ying</au><au>Guan, Yifu</au><au>Yang, Hua</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Preparation and Release of pH-Sensitive β-Cyclodextrin Derivative Micelles Loaded with Paclitaxel</atitle><jtitle>Polymers</jtitle><date>2022-06-18</date><risdate>2022</risdate><volume>14</volume><issue>12</issue><spage>2482</spage><pages>2482-</pages><issn>2073-4360</issn><eissn>2073-4360</eissn><abstract>In this paper, a new amphiphilic mono-6-β-cyclodextrin octadecylimine (6-β-CD-N-ODMA) copolymer was synthesized based on β-cyclodextrin and octadecylamine, which can self-assemble to form polymeric micelles. Drug-loaded micelles (a new drug carrier) were obtained using 6-β-CD-N-ODMA and paclitaxel (PTX) by the dialysis method. Orthogonal experiments were used to optimize the preparation method of the drug-loaded micelles. The drug-loading content of the carrier prepared by the optimized method was 1.97%. The physicochemical properties of blank micelles and drug-loaded micelles were evaluated by the fluorescence probe method, infrared spectra, dynamic light scattering, and scanning electron microscopy. The release properties of the carrier were investigated. The carrier has good pH sensitivity and the cumulative release rate after 96 h was 88% in PBS (pH = 5.0). The Ritger–Peppas equation is the optimal model for PTX released at pH 5.0, implying that the hydrolysis effect of 6-β-CD-N-ODMA is the main reason for PTX release. The results indicate that the developed carrier can increase the solubility of PTX and possess potential for increased clinical efficacy of PTX.</abstract><cop>Basel</cop><pub>MDPI AG</pub><pmid>35746058</pmid><doi>10.3390/polym14122482</doi><orcidid>https://orcid.org/0000-0003-0886-5204</orcidid><oa>free_for_read</oa></addata></record> |
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| subjects | Cancer therapies Copolymers Cyclodextrins Dosage and administration Drug carriers Drug delivery systems Drugs Efficiency Fluorescent indicators Hemodialysis Infrared spectra Methods Micelles Optimization Paclitaxel Photon correlation spectroscopy Vehicles |
| title | Preparation and Release of pH-Sensitive β-Cyclodextrin Derivative Micelles Loaded with Paclitaxel |
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