The pharmacokinetic property and pharmacological activity of acteoside: A review
Acteoside (AC), a phenylpropanoid glycoside isolated from many dicotyledonous plants, has been demonstrated various pharmacological activities, including anti-oxidation, anti-inflammation, anti-cancer, neuroprotection, cardiovascular protection, anti-diabetes, bone and cartilage protection, hepatopr...
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| Veröffentlicht in: | Biomedicine & pharmacotherapy 2022-09, Vol.153, p.113296-113296, Article 113296 |
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| creator | Xiao, Yaosheng Ren, Qun Wu, Longhuo |
| description | Acteoside (AC), a phenylpropanoid glycoside isolated from many dicotyledonous plants, has been demonstrated various pharmacological activities, including anti-oxidation, anti-inflammation, anti-cancer, neuroprotection, cardiovascular protection, anti-diabetes, bone and cartilage protection, hepatoprotection, and anti-microorganism. However, AC has a poor bioavailability, which can be potentially improved by different strategies. The health-promoting characteristics of AC can be attributed to its mediation in many signaling pathways, such as MAPK, NF-κB, PI3K/AKT, TGFβ/Smad, and AMPK/mTOR. Interestingly, docking simulation study indicates that AC can be an effective candidate to inhibit the activity of SARS-CoV2 main protease and protect against COVID-19. Many clinical trials for AC have been investigated, and it shows great potentials in drug development.
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•Acteoside is a phenylpropanoid glycoside highly available in dicotyledonous plants.•Acteoside exhibits a variety of pharmacological activities.•This review mainly focuses on the pharmacological activity of acteoside. |
| doi_str_mv | 10.1016/j.biopha.2022.113296 |
| format | Article |
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[Display omitted]
•Acteoside is a phenylpropanoid glycoside highly available in dicotyledonous plants.•Acteoside exhibits a variety of pharmacological activities.•This review mainly focuses on the pharmacological activity of acteoside.</description><identifier>ISSN: 0753-3322</identifier><identifier>EISSN: 1950-6007</identifier><identifier>DOI: 10.1016/j.biopha.2022.113296</identifier><identifier>PMID: 35724511</identifier><language>eng</language><publisher>France: Elsevier Masson SAS</publisher><subject>Acteoside ; Anti-inflammation ; Anti-oxidation ; COVID-19 Drug Treatment ; Glucosides ; Humans ; Neuroprotection ; NF-kappa B - metabolism ; Phosphatidylinositol 3-Kinases - metabolism ; Polyphenols ; Review ; RNA, Viral ; SARS-CoV-2</subject><ispartof>Biomedicine & pharmacotherapy, 2022-09, Vol.153, p.113296-113296, Article 113296</ispartof><rights>2022 The Authors</rights><rights>Copyright © 2022 The Authors. Published by Elsevier Masson SAS.. All rights reserved.</rights><rights>2022 The Authors 2022</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c529t-eecd5d3d517307ebec55c70d39d552eb4da167965e56eea933fab313683019903</citedby><cites>FETCH-LOGICAL-c529t-eecd5d3d517307ebec55c70d39d552eb4da167965e56eea933fab313683019903</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://dx.doi.org/10.1016/j.biopha.2022.113296$$EHTML$$P50$$Gelsevier$$Hfree_for_read</linktohtml><link.rule.ids>230,314,780,784,885,3550,27924,27925,45995</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/35724511$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xiao, Yaosheng</creatorcontrib><creatorcontrib>Ren, Qun</creatorcontrib><creatorcontrib>Wu, Longhuo</creatorcontrib><title>The pharmacokinetic property and pharmacological activity of acteoside: A review</title><title>Biomedicine & pharmacotherapy</title><addtitle>Biomed Pharmacother</addtitle><description>Acteoside (AC), a phenylpropanoid glycoside isolated from many dicotyledonous plants, has been demonstrated various pharmacological activities, including anti-oxidation, anti-inflammation, anti-cancer, neuroprotection, cardiovascular protection, anti-diabetes, bone and cartilage protection, hepatoprotection, and anti-microorganism. However, AC has a poor bioavailability, which can be potentially improved by different strategies. The health-promoting characteristics of AC can be attributed to its mediation in many signaling pathways, such as MAPK, NF-κB, PI3K/AKT, TGFβ/Smad, and AMPK/mTOR. Interestingly, docking simulation study indicates that AC can be an effective candidate to inhibit the activity of SARS-CoV2 main protease and protect against COVID-19. Many clinical trials for AC have been investigated, and it shows great potentials in drug development.
[Display omitted]
•Acteoside is a phenylpropanoid glycoside highly available in dicotyledonous plants.•Acteoside exhibits a variety of pharmacological activities.•This review mainly focuses on the pharmacological activity of acteoside.</description><subject>Acteoside</subject><subject>Anti-inflammation</subject><subject>Anti-oxidation</subject><subject>COVID-19 Drug Treatment</subject><subject>Glucosides</subject><subject>Humans</subject><subject>Neuroprotection</subject><subject>NF-kappa B - metabolism</subject><subject>Phosphatidylinositol 3-Kinases - metabolism</subject><subject>Polyphenols</subject><subject>Review</subject><subject>RNA, Viral</subject><subject>SARS-CoV-2</subject><issn>0753-3322</issn><issn>1950-6007</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2022</creationdate><recordtype>article</recordtype><sourceid>EIF</sourceid><recordid>eNp9UctOwzAQtBCIlscfIJQjlwQ_arvmgFRVvKRKcICz5dhb6pLGwU6L-vekKhS4cNqVZndmdwahM4ILgom4nBelD83MFBRTWhDCqBJ7qE8Ux7nAWO6jPpac5YxR2kNHKc0xxlyw4SHqMS7pgBPSR0_PM8g6lrgwNrz5GlpvsyaGBmK7zkztdmAVXr01VWZs61e-A8N000NI3sFVNsoirDx8nKCDqakSnH7VY_Rye_M8vs8nj3cP49Ekt5yqNgewjjvmOJEMSyjBcm4ldkw5zimUA2eIkEpw4ALAKMampmSEiSHDRCnMjtH1lrdZlgtwFuo2mko30S9MXOtgvP6L1H6mX8NKK0qolKojuPgiiOF9CanVC58sVJWpISyTpp08ZWLAZTc62I7aGFKKMN3JEKw3Yei53oahN2HobRjd2vnvE3dL3-7__ACdUZ15USfrobbgfATbahf8_wqfQcKeeQ</recordid><startdate>20220901</startdate><enddate>20220901</enddate><creator>Xiao, Yaosheng</creator><creator>Ren, Qun</creator><creator>Wu, Longhuo</creator><general>Elsevier Masson SAS</general><general>The Author(s). Published by Elsevier Masson SAS</general><scope>6I.</scope><scope>AAFTH</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>5PM</scope></search><sort><creationdate>20220901</creationdate><title>The pharmacokinetic property and pharmacological activity of acteoside: A review</title><author>Xiao, Yaosheng ; Ren, Qun ; Wu, Longhuo</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c529t-eecd5d3d517307ebec55c70d39d552eb4da167965e56eea933fab313683019903</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2022</creationdate><topic>Acteoside</topic><topic>Anti-inflammation</topic><topic>Anti-oxidation</topic><topic>COVID-19 Drug Treatment</topic><topic>Glucosides</topic><topic>Humans</topic><topic>Neuroprotection</topic><topic>NF-kappa B - metabolism</topic><topic>Phosphatidylinositol 3-Kinases - metabolism</topic><topic>Polyphenols</topic><topic>Review</topic><topic>RNA, Viral</topic><topic>SARS-CoV-2</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xiao, Yaosheng</creatorcontrib><creatorcontrib>Ren, Qun</creatorcontrib><creatorcontrib>Wu, Longhuo</creatorcontrib><collection>ScienceDirect Open Access Titles</collection><collection>Elsevier:ScienceDirect:Open Access</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Biomedicine & pharmacotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xiao, Yaosheng</au><au>Ren, Qun</au><au>Wu, Longhuo</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The pharmacokinetic property and pharmacological activity of acteoside: A review</atitle><jtitle>Biomedicine & pharmacotherapy</jtitle><addtitle>Biomed Pharmacother</addtitle><date>2022-09-01</date><risdate>2022</risdate><volume>153</volume><spage>113296</spage><epage>113296</epage><pages>113296-113296</pages><artnum>113296</artnum><issn>0753-3322</issn><eissn>1950-6007</eissn><abstract>Acteoside (AC), a phenylpropanoid glycoside isolated from many dicotyledonous plants, has been demonstrated various pharmacological activities, including anti-oxidation, anti-inflammation, anti-cancer, neuroprotection, cardiovascular protection, anti-diabetes, bone and cartilage protection, hepatoprotection, and anti-microorganism. However, AC has a poor bioavailability, which can be potentially improved by different strategies. The health-promoting characteristics of AC can be attributed to its mediation in many signaling pathways, such as MAPK, NF-κB, PI3K/AKT, TGFβ/Smad, and AMPK/mTOR. Interestingly, docking simulation study indicates that AC can be an effective candidate to inhibit the activity of SARS-CoV2 main protease and protect against COVID-19. Many clinical trials for AC have been investigated, and it shows great potentials in drug development.
[Display omitted]
•Acteoside is a phenylpropanoid glycoside highly available in dicotyledonous plants.•Acteoside exhibits a variety of pharmacological activities.•This review mainly focuses on the pharmacological activity of acteoside.</abstract><cop>France</cop><pub>Elsevier Masson SAS</pub><pmid>35724511</pmid><doi>10.1016/j.biopha.2022.113296</doi><tpages>1</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0753-3322 |
| ispartof | Biomedicine & pharmacotherapy, 2022-09, Vol.153, p.113296-113296, Article 113296 |
| issn | 0753-3322 1950-6007 |
| language | eng |
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| source | MEDLINE; Elsevier ScienceDirect Journals Complete; EZB-FREE-00999 freely available EZB journals |
| subjects | Acteoside Anti-inflammation Anti-oxidation COVID-19 Drug Treatment Glucosides Humans Neuroprotection NF-kappa B - metabolism Phosphatidylinositol 3-Kinases - metabolism Polyphenols Review RNA, Viral SARS-CoV-2 |
| title | The pharmacokinetic property and pharmacological activity of acteoside: A review |
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