The pharmacokinetic property and pharmacological activity of acteoside: A review
Acteoside (AC), a phenylpropanoid glycoside isolated from many dicotyledonous plants, has been demonstrated various pharmacological activities, including anti-oxidation, anti-inflammation, anti-cancer, neuroprotection, cardiovascular protection, anti-diabetes, bone and cartilage protection, hepatopr...
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Veröffentlicht in: | Biomedicine & pharmacotherapy 2022-09, Vol.153, p.113296-113296, Article 113296 |
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Format: | Artikel |
Sprache: | eng |
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Zusammenfassung: | Acteoside (AC), a phenylpropanoid glycoside isolated from many dicotyledonous plants, has been demonstrated various pharmacological activities, including anti-oxidation, anti-inflammation, anti-cancer, neuroprotection, cardiovascular protection, anti-diabetes, bone and cartilage protection, hepatoprotection, and anti-microorganism. However, AC has a poor bioavailability, which can be potentially improved by different strategies. The health-promoting characteristics of AC can be attributed to its mediation in many signaling pathways, such as MAPK, NF-κB, PI3K/AKT, TGFβ/Smad, and AMPK/mTOR. Interestingly, docking simulation study indicates that AC can be an effective candidate to inhibit the activity of SARS-CoV2 main protease and protect against COVID-19. Many clinical trials for AC have been investigated, and it shows great potentials in drug development.
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•Acteoside is a phenylpropanoid glycoside highly available in dicotyledonous plants.•Acteoside exhibits a variety of pharmacological activities.•This review mainly focuses on the pharmacological activity of acteoside. |
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ISSN: | 0753-3322 1950-6007 |
DOI: | 10.1016/j.biopha.2022.113296 |