Post-Translational Modifications of BACE1 in Alzheimer's Disease

Beta-Amyloid Cleaving Enzyme1 (BACE1) is a monospecific enzyme for the key ratelimitingstep in the synthesis of beta-amyloid(Aβ) from cleavage of amyloid precursor protein (APP),to form senile plaques and causes cognitive dysfunction in Alzheimer's disease (AD). Post-translationmodifications of BACE1, such as acetylation, glycosylation, palmitoylation, phosphorylation,play a crucial role in the trafficking and maturation process of BACE1. The study of BACE1is of great importance not only for understanding the formation of toxic Aβ but also for the developmentof an effective therapeutic target for the treatment of AD. This paper review recent advancesin the studies about BACE1, with focuses being paid to the relationship of Aβ, BACE1 with posttranslationalregulation of BACE1. In addition, we specially reviewed studies about the compoundsthat can be used to affect post-translational regulation of BACE1 or regulate BACE1 in theliterature, which can be used for subsequent research on whether BACE1 is a post-translationallymodified drug.