Sensitivity of Myocardial Radiomic Features to Imaging Parameters in Cardiac MR Imaging

Background Cardiac magnetic resonance (MR) images are often collected with different imaging parameters, which may impact the calculated values of myocardial radiomic features. Purpose To investigate the sensitivity of myocardial radiomic features to changes in imaging parameters in cardiac MR images. Study Type Prospective. Population A total of 11 healthy participants/five patients. Field Strength/ Sequence A 3 T/cine balanced steady‐state free‐precession, T1‐weighted spoiled gradient‐echo, T2‐weighted turbo spin‐echo, and quantitative T1 and T2 mapping. For each sequence, the flip angle, in‐plane resolution, slice thickness, and parallel imaging technique were varied to study the sensitivity of radiomic features to alterations in imaging parameters. Assessment Myocardial contours were manually delineated by experienced readers, and a total of 1023 radiomic features were extracted using PyRadiomics with 11 image filters and six feature families. Statistical Tests Sensitivity was defined as the standardized mean difference (D effect size), and the robust features were defined at sensitivity