Endosomal trafficking in schizophrenia

Schizophrenia is a severe and heritable neuropsychiatric disorder, which arises due to a combination of common genetic variation, rare loss of function variation, and copy number variation. Functional genomic evidence has been used to identify candidate genes affected by this variation, which revealed biological pathways that may be disrupted in schizophrenia. Understanding the contributions of these pathways are critical next steps in understanding schizophrenia pathogenesis. A number of genes involved in endocytosis are implicated in schizophrenia. In this review, we explore the history of endosomal trafficking in schizophrenia and highlight new endosomal candidate genes. We explore the function of these candidate genes and hypothesize how their dysfunction may contribute to schizophrenia. •Common genetic variation in schizophrenia is primarily non-coding.•Quantitative data link schizophrenia variants to genes.•Candidate genes for schizophrenia risk function in endosomal trafficking.•Endosomal trafficking is critical for processes dysregulated in schizophrenia.