DDEL-06. Drug Delivery to the Pons Using Short-Pulse Focused Ultrasound and Microbubble Exposure for the Treatment of Diffuse Midline Glioma

DDEL-06. Drug Delivery to the Pons Using Short-Pulse Focused Ultrasound and Microbubble Exposure for the Treatment of Diffuse Midline Glioma

Despite advances in understanding diffuse midline glioma (DMG-H3K27), including DIPG, there are still no effective treatments available, and the dismal clinical prognosis remains. This is partly because of tumour spread behind an intact blood brain barrier (BBB), preventing drug delivery and the rea...

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Veröffentlicht in:Neuro-oncology (Charlottesville, Va.) Va.), 2022-06, Vol.24 (Supplement_1), p.i35-i35
Hauptverfasser: Chattenton, Dani, Rivens, Ian, Jiang, Zheng, Carvalho, Diana M, Sujarittam, Krit, Boult, Jessica K R, Robinson, Simon P, Jones, Chris, ter Haar, Gail, Choi, James
Format: Artikel
Sprache:eng
Schlagworte:
Drug Delivery/Pharmacokinetics
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Zusammenfassung:Despite advances in understanding diffuse midline glioma (DMG-H3K27), including DIPG, there are still no effective treatments available, and the dismal clinical prognosis remains. This is partly because of tumour spread behind an intact blood brain barrier (BBB), preventing drug delivery and the reason for many drugs failing in the clinic. The use of focused ultrasound and intravenous microbubbles enables temporary increases in BBB permeability, allowing drugs to enter the targeted brain region. Building on recent research demonstrating that short pulses (
ISSN:1522-8517
1523-5866
DOI:10.1093/neuonc/noac079.127