T-cell immune response predicts the risk of critical SARS-Cov2 infection in hospitalized COVID-19 patients

•Th17 cells are increased in patients who progress to critical Covid-19.•In severe Covid-19, Th17>0.435% of CD4 t cells is associated with poorer survival.Assessment of Th17 cells could help target patients in need of anti-IL6R therapy. This study aimed to identify markers of disease worsening in...

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Veröffentlicht in:	European journal of internal medicine 2022-08, Vol.102, p.104-109
Hauptverfasser:	Samson, Maxime, Nicolas, Barbara, Ciudad, Marion, Greigert, Hélène, Guilhem, Alexandre, Cladiere, Claudie, Straub, Cécile, Blot, Mathieu, Piroth, Lionel, Rogier, Thomas, Devilliers, Hervé, Manckoundia, Patrick, Ghesquiere, Thibault, Francois, Stéphanie, Lakomy, Daniela, Audia, Sylvain, Bonnotte, Bernard
Format:	Artikel
Sprache:	eng
Schlagworte:	COVID-19 Female Humans IL-6 Immunity Interleukin-6 Male Original RNA, Viral SARS Cov2 SARS-CoV-2 T-Lymphocytes Th17 cells
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Zusammenfassung:	•Th17 cells are increased in patients who progress to critical Covid-19.•In severe Covid-19, Th17>0.435% of CD4 t cells is associated with poorer survival.Assessment of Th17 cells could help target patients in need of anti-IL6R therapy. This study aimed to identify markers of disease worsening in patients hospitalized for SARS-Cov2 infection. Patients hospitalized for severe recent-onset (
ISSN:	0953-6205 1879-0828
DOI:	10.1016/j.ejim.2022.06.001