CBFB-MYH11 fusion transcripts distinguish acute myeloid leukemias with distinct molecular landscapes and outcomes

•CBFB-MYH11 transcripts and KIT mutations predict relapse in AML.•High-risk CBFB-MYH11 transcripts are associated with distinct transcriptional landscapes and upregulation of early hematopoiesis genes.

Gespeichert in:

Bibliographische Detailangaben
Veröffentlicht in:	Blood advances 2021-12, Vol.5 (23), p.4963-4968
Hauptverfasser:	Huang, Benjamin J., Smith, Jenny L., Wang, Yi-Cheng, Taghizadeh, Kassra, Leonti, Amanda R., Ries, Rhonda E., Liu, Yanling, Kolekar, Pandurang, Tarlock, Katherine, Gerbing, Robert, Crowgey, Erin, Furlan, Scott N., Shaw, Timothy I., Hagiwara, Kohei, Wei, Lisa, Cooper, Todd M., Gamis, Alan S., Aplenc, Richard, Kolb, E. Anders, Farrar, Jason E., Triche, Timothy, Alonzo, Todd A., Ma, Xiaotu, Meshinchi, Soheil
Format:	Artikel
Sprache:	eng
Schlagworte:	Core Binding Factor beta Subunit Humans Leukemia, Myeloid, Acute - diagnosis Leukemia, Myeloid, Acute - genetics Myosin Heavy Chains Oncogene Proteins, Fusion - genetics Stimulus Report
Online-Zugang:	Volltext
Tags:	Tag hinzufügen Keine Tags, Fügen Sie den ersten Tag hinzu!

Beschreibung
Zusammenfassung:	•CBFB-MYH11 transcripts and KIT mutations predict relapse in AML.•High-risk CBFB-MYH11 transcripts are associated with distinct transcriptional landscapes and upregulation of early hematopoiesis genes.
ISSN:	2473-9529 2473-9537
DOI:	10.1182/bloodadvances.2021004965