Exosomes as novel biomarkers in metabolic disease and obesity-related cancers

Exosomes include plasma-transported vesicles that are secreted by human tissues and reflect metabolic status. The profile of exosomes (particularly microRNA content) is altered in metabolic disease. In type 2 diabetes mellitus, exosomes circulating in plasma induce transcriptional changes related to...

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Veröffentlicht in:	Nature reviews. Endocrinology 2022-06, Vol.18 (6), p.327-328
Hauptverfasser:	Jafari, Naser, Llevenes, Pablo, Denis, Gerald V.
Format:	Artikel
Sprache:	eng
Schlagworte:	631/67 692/163 Biomarkers - metabolism Comment Diabetes mellitus (non-insulin dependent) Endocrinology Exosomes Exosomes - metabolism Humans Medicine Medicine & Public Health Metabolic Diseases - diagnosis Metabolic Diseases - metabolism Metabolic disorders Metastases miRNA Neoplasms - diagnosis Neoplasms - metabolism Obesity Obesity - complications Obesity - metabolism Phenotypes Tumors
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Beschreibung
Zusammenfassung:	Exosomes include plasma-transported vesicles that are secreted by human tissues and reflect metabolic status. The profile of exosomes (particularly microRNA content) is altered in metabolic disease. In type 2 diabetes mellitus, exosomes circulating in plasma induce transcriptional changes related to tumour progression and pro-metastatic phenotypes in target cancer cells, potentially linking obesity to cancer progression and metastasis.
ISSN:	1759-5029 1759-5037 1759-5037
DOI:	10.1038/s41574-022-00666-7